The Importance of Specific Lge Investigation on Diagnosis of Allergic Diseases

Abstract

When suspecting an allergic disease, it should be confirmed using special tests. in this study, 79 pati­ ents who were followed up by outpatient department of Allergy of Dr. Behçet Uz Children's Hospital was examined. Twenty healthy children were served as the control group. We aimed to determine the importance of skin tests by comparing specific lgE and total IgE levels by EIA of patients having allergic complaints. The 47 (59%) of the patients was male and 32 (41%) female. Average age was 107.55 ±27.82 months. The 13 (65%) ofthe control group was male, 7 (35%)female and the average age was 108.5 ±24.5 months. Patients were dispersed in a broad range diagnosis spectrum from asthma bronchiale (AB) to AB+allergic rinit, urticaria, allergic conjunctivitis. Levels of total and specific JgE were determined, scratch and intradermal skin tests were performed to the patients. Total and specific lgE levels of the control group were studied. in laboratory findings which were made for supporting the diagnosis, 59% was positive for total lgE, 52% and 85% was positive for scratch and intradermal skin tests respectively. Specific lgE levels were found 7I % positive. in our study, while the sensitivity and specifity of total lgE were found 58.2% and 33.3% respectively, for specific lgE, they were found 80.5% and 83.3%. Since specific lgE which was determined by EL/SA method was found highly specific and effective, we can easily claim that it is a reliable diagnostic technique which can be used in the diagnosis of allergic diseases.