Effect Mechanism Of Immunosupressive Drugs

Tülay Kılıçaslan AYNA; Hayriye Şentürk ÇİFTÇİ; Hilmi TOZKIR; Mehmet GÜRTEKİN; Mahmut ÇARİN

doi:10.58600/eurjther.2009-15-3-1390-arch

Authors

Tülay Kılıçaslan AYNA İstanbul Üniversitesi İstanbul Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı
Hayriye Şentürk ÇİFTÇİ İstanbul Üniversitesi İstanbul Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı
Hilmi TOZKIR Trakya Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı
Mehmet GÜRTEKİN İstanbul Üniversitesi İstanbul Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı
Mahmut ÇARİN İstanbul Üniversitesi İstanbul Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı

DOI:

https://doi.org/10.58600/eurjther.2009-15-3-1390-arch

Keywords:

Organ transplantation, Immunosuppressive therapy

Abstract

Effective immunosuppression is a key to successful organ transplantation. This study will provide an overview of different immunosuppressive agents used in solid organ transplantation. An increasing number of immunosuppressive agents are available and these agents target different steps of the immunological response to an allograft. These immunosuppressive agents are steroids, anti- proliferative agents (azathioprine and mycophenolate), calcineurin inhibitors (cyclosporine and tacrolimus), TOR inhibitors (sirolimus and everolimus), polyclonal and monoclonal antibody preparations.

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