Approaches To Anti-HLA Antibody Profiles In Patients Waiting For Renal Re-Transplantation

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  • Gonca Emel KARAHAN İstanbul Üniversitesi İstanbul Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı
  • Fatma Savran OĞUZ İstanbul Üniversitesi İstanbul Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı
  • Mahmut N. Çarin İstanbul Üniversitesi İstanbul Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı



Renal re-transplantation, Anti-HLA antibodies, Anti-MICA antibodies, HLAMatchmaker, Nephrectomy


This review focuses on the mechanisms of anti-HLA antibody development in patients waiting for a renal re-transplantation. Pre- existence or post transplant de novo production of these antibodies have been found to contribute to renal allograft failure in years. In addition to the detrimental effect of donor specific and non-donor specific anti-HLA antibodies on graft survival, many researchers emphasized the effect of non-HLA antibodies (e.g.; anti-MICA antibodies), auto-antibodies (e.g.; anti-vimentin antibodies), allo-nephrectomy and combined liver-kidney transplantations on rejection processes. Beyond all these, a newly developed computer algorithm, 'HLAMatchmaker' has changed the concept of transplantation possibility in highly sensitized patients.


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How to Cite

KARAHAN, G. E., OĞUZ, F. S., & Çarin, M. N. (2009). Approaches To Anti-HLA Antibody Profiles In Patients Waiting For Renal Re-Transplantation. European Journal of Therapeutics, 15(3), 36–41.



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