The Possible Role of 3':5'- Cyclic Guanosine Monophosphate in Acetylcholine-Mediated Concraction of Isolated Rat Duodenum

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  • Aydın ERENMEMİŞOĞLU Erciyes Üniversitesi Tıp Fakültesi Farmakoloji ABD.Yrd.Doç.Dr.
  • Cem SÜER Erciyes Üniversitesi Tıp Fakültesi Fizyoloji ABD.Doç.Dr.
  • Sadun TEMOÇİN Çukurova Üniversitesi Tıp Fakültesi Fizyoloji ABD.Yrd.Doç.Dr.
  • Hüseyin BEYDAĞI Gaziantep Üniversitesi Tıp Fakültesi Fizyoloji ABD.Yrd.Doç.Dr.



Acetylcholine, 3':5'-cyclic guanosine monophosphate, sodium nitroprusside, methylene blue


This study was planned to determine whether the possible role of 3':5'-cyclic guanosine monophosphate (cylic GMP) on acetylcholine(ACh) action in isolated rat duodenum. Therefore, sodium nitroprusside(SNP) and methylene blue(MB) were used as a guanylate cyclase activator and inhibitor respectively. MB caused significant fall in ACh-induced contraction peaks, whereas SNP did not alter them. These results suggested that cyclic GMP may play a role for ACh action in isolated duodenum smooth muscle. However further experiments are necessary to determine whether a causal relationship exists between cyclic GMP and ACh action.


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How to Cite

ERENMEMİŞOĞLU, A., SÜER, C., TEMOÇİN, S., & BEYDAĞI, H. (1994). The Possible Role of 3’:5’- Cyclic Guanosine Monophosphate in Acetylcholine-Mediated Concraction of Isolated Rat Duodenum. European Journal of Therapeutics, 5(1), 16–20.



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