The Possible Role of 3':5'- Cyclic Guanosine Monophosphate in Acetylcholine-Mediated Concraction of Isolated Rat Duodenum

Aydın ERENMEMİŞOĞLU; Cem SÜER; Sadun TEMOÇİN; Hüseyin BEYDAĞI

doi:10.58600/eurjther.1994-5-1-1369-arch

Authors

Aydın ERENMEMİŞOĞLU Erciyes Üniversitesi Tıp Fakültesi Farmakoloji ABD.Yrd.Doç.Dr.
Cem SÜER Erciyes Üniversitesi Tıp Fakültesi Fizyoloji ABD.Doç.Dr.
Sadun TEMOÇİN Çukurova Üniversitesi Tıp Fakültesi Fizyoloji ABD.Yrd.Doç.Dr.
Hüseyin BEYDAĞI Gaziantep Üniversitesi Tıp Fakültesi Fizyoloji ABD.Yrd.Doç.Dr.

DOI:

https://doi.org/10.58600/eurjther.1994-5-1-1369-arch

Keywords:

Acetylcholine, 3':5'-cyclic guanosine monophosphate, sodium nitroprusside, methylene blue

Abstract

This study was planned to determine whether the possible role of 3':5'-cyclic guanosine monophosphate (cylic GMP) on acetylcholine(ACh) action in isolated rat duodenum. Therefore, sodium nitroprusside(SNP) and methylene blue(MB) were used as a guanylate cyclase activator and inhibitor respectively. MB caused significant fall in ACh-induced contraction peaks, whereas SNP did not alter them. These results suggested that cyclic GMP may play a role for ACh action in isolated duodenum smooth muscle. However further experiments are necessary to determine whether a causal relationship exists between cyclic GMP and ACh action.

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