The Possible Role of 3':5'- Cyclic Guanosine Monophosphate in Acetylcholine-Mediated Concraction of Isolated Rat Duodenum


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Authors

  • Aydın ERENMEMİŞOĞLU Erciyes Üniversitesi Tıp Fakültesi Farmakoloji ABD.Yrd.Doç.Dr.
  • Cem SÜER Erciyes Üniversitesi Tıp Fakültesi Fizyoloji ABD.Doç.Dr.
  • Sadun TEMOÇİN Çukurova Üniversitesi Tıp Fakültesi Fizyoloji ABD.Yrd.Doç.Dr.
  • Hüseyin BEYDAĞI Gaziantep Üniversitesi Tıp Fakültesi Fizyoloji ABD.Yrd.Doç.Dr.

DOI:

https://doi.org/10.58600/eurjther.1994-5-1-1369-arch

Keywords:

Acetylcholine, 3':5'-cyclic guanosine monophosphate, sodium nitroprusside, methylene blue

Abstract

This study was planned to determine whether the possible role of 3':5'-cyclic guanosine monophosphate (cylic GMP) on acetylcholine(ACh) action in isolated rat duodenum. Therefore, sodium nitroprusside(SNP) and methylene blue(MB) were used as a guanylate cyclase activator and inhibitor respectively. MB caused significant fall in ACh-induced contraction peaks, whereas SNP did not alter them. These results suggested that cyclic GMP may play a role for ACh action in isolated duodenum smooth muscle. However further experiments are necessary to determine whether a causal relationship exists between cyclic GMP and ACh action.

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References

lgnarro LJ., Burke TM., Woods KS., et all.:Assodation between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery. J Pharmacol Exp Ther 228:682-690, 1984.

Bolton TB.:Mechanisms of action of transmitters and other subtances on smooth muscle. Physiol Rev 59:607-718, 1979.

Furchgott RF., Zawadziki JV.:The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature(Lond.) 288:373-376, 1980.

Schultz KD., Schiltz K., Schultz G.:Sodium nitroprusside and other smooth muscle relaxants increase cyclic GMP levels in rat ductus deferens. Nature (lond) 288:750-751, 1979.

Fujitani Y., Ueda H., Okada T., Urade Y., Kraki H.:A selective agonist of endothelin type B receptor, IRL 1620, stimulates cyclic GMP increase via nitric oxide formation in rat aorta. J Pharm Exp Ther 267:683-689, 1993.

Süer C., Erenmemişoğlu A., Temoçin S., Akar S., Beydağı H., Taspolat l.:lnfluence of calcium removal from bath solution on isolated rat duodenum contractions. Indian J Physiol Pharmacol 36:181-184, 1992.

Ross EM.,1990 Pharmacodynamics:Mechanism of drug action and the relationship between drug concentration and effect. In:The Pharmacological Basis of Therapeutics.(8 th ed) Gilman AG, Rall TW, Nies AS, Taylor P Eds. New York, Pergamon Press; 1990:166-186.

Lee T., Kuo JF.:Role of muscarinic cholinergic receptors in regulation of guanosine 3':5'-cyclic monophosphate content in mammalian brain, hearth muscle and intestinal smooth muscle, Proc Natl Acad Sci(USA). 69:3287-3291, 1972.

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Published

1994-01-01

How to Cite

ERENMEMİŞOĞLU, A., SÜER, C., TEMOÇİN, S., & BEYDAĞI, H. (1994). The Possible Role of 3’:5’- Cyclic Guanosine Monophosphate in Acetylcholine-Mediated Concraction of Isolated Rat Duodenum. European Journal of Therapeutics, 5(1), 16–20. https://doi.org/10.58600/eurjther.1994-5-1-1369-arch

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Original Articles