No Association Between Myeloperoxidase Gene G-463A Polymorphism And Rheumatoid Arthritis
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DOI:
https://doi.org/10.58600/eurjther.2009-15-3-1358-archKeywords:
MPO gene, G-463A Promoter polymorphism, Rheumotaid Artritis, PCR-RFLPAbstract
Myeloperoxidase (MPO) has been involved in the pathogenesis of several diseases such as rheumatoid arthritis (RA) through excessive production of reactive oxygen species (ROS) as well as through its genetic polymorphism. We examined whether G-463A polymorphism of Myeloperoxidase (MPO) gene was associated with RA. Exactly, 75 patients with RA and 90 healthy control subjects were included in this study. The genotyping was determined by polymerase chain reaction- restriction fragment length polymorphism method. The association between these single nucleotide polymorphism (SNP) and RA was analyzed using chi-square test and de-Finetti program. Genotype distributions and allele frequency of RA patients were not significantly different from healthy controls. In addition, it was also determined that there was no deviation from Hardy-Weinberg Equilibrium in any groups (p>0.05). Whether there was an association between MPO gene G-463A gene polymorphism and RA was investigated for the first time in this study in literature and it was demonstrated that it did not exist in the Turkish RA patients. It was planned to investigate the other polymorphisms of MPO gene in the future.
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