No Association Between Myeloperoxidase Gene G-463A Polymorphism And Rheumatoid Arthritis


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Authors

  • Sacide PEHLİVAN Gaziantep University Faculty of Medicine, Department of Medical Biology and Genetics
  • Ali AYDENİZ University Faculty of Medicine, Department of Physical Medicine and Rehabilitation
  • Tuğçe SEVER Gaziantep University Faculty of Medicine, Department of Medical Biology and Genetics
  • Özlem ALTINDAĞ Gaziantep University Faculty of Medicine, Department of Physical Medicine and Rehabilitation
  • Sibel OĞUZKAN BALCI Gaziantep University Faculty of Medicine, Department of Medical Biology and Genetics
  • Türkan HARUNLAR Gaziantep University Faculty of Medicine, Department of Physical Medicine and Rehabilitation

DOI:

https://doi.org/10.58600/eurjther.2009-15-3-1358-arch

Keywords:

MPO gene, G-463A Promoter polymorphism, Rheumotaid Artritis, PCR-RFLP

Abstract

Myeloperoxidase (MPO) has been involved in the pathogenesis of several diseases such as rheumatoid arthritis (RA) through excessive production of reactive oxygen species (ROS) as well as through its genetic polymorphism. We examined whether G-463A polymorphism of Myeloperoxidase (MPO) gene was associated with RA. Exactly, 75 patients with RA and 90 healthy control subjects were included in this study. The genotyping was determined by polymerase chain reaction- restriction fragment length polymorphism method. The association between these single nucleotide polymorphism (SNP) and RA was analyzed using chi-square test and de-Finetti program. Genotype distributions and allele frequency of RA patients were not significantly different from healthy controls. In addition, it was also determined that there was no deviation from Hardy-Weinberg Equilibrium in any groups (p>0.05). Whether there was an association between MPO gene G-463A gene polymorphism and RA was investigated for the first time in this study in literature and it was demonstrated that it did not exist in the Turkish RA patients. It was planned to investigate the other polymorphisms of MPO gene in the future.

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Published

2009-09-01

How to Cite

PEHLİVAN , S., AYDENİZ , A., SEVER , T., ALTINDAĞ , Özlem, OĞUZKAN BALCI, S., & HARUNLAR, T. (2009). No Association Between Myeloperoxidase Gene G-463A Polymorphism And Rheumatoid Arthritis. European Journal of Therapeutics, 15(3), 14–16. https://doi.org/10.58600/eurjther.2009-15-3-1358-arch

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Section

Clinical Research