The Comparison of the Urea Breath Test and the Rapid Casette Test (Card Test) in Diagnosis of Helicobacter Pylori

Murat Mehli; Tekin Karslığil; Sadık Akgün; Mehmet Koruk

doi:10.58600/eurjther.2008-14-1-1348-arch

Authors

Murat Mehli Gaziantep Üniversitesi Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji AD
Tekin Karslığil Gaziantep Üniversitesi Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji AD
Sadık Akgün Gaziantep Üniversitesi Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji AD
Mehmet Koruk Gaziantep Üniversitesi Tıp Fakültesi Gastroenteroloji BD

DOI:

https://doi.org/10.58600/eurjther.2008-14-1-1348-arch

Keywords:

Helicobacter pylori, Urea Breath Test (UBT), Rapid Casette Test

Abstract

The purpose of this study is to determine sensitivity of the rapid H. pylori casette test in patients who were admitted to hospital with epigastric pain, and who were diagnosed with H. pylori positivity with the urea breath test, and to also analyze the role of the two tests in diagnosis. A total of 149 patients, 71 (48%) males, and 78 females (52%) with an average age of 41, who were admitted to Gaziantep University Faculty of Medicine Gasroenterology Polyclinic with epigastric pain were included in the study. The urea breath test was applied to the patients and separating serum from venous blood which was taken simultaneously, with the chromatographic immunoassay method (Cart test) (Medisera Diag. Inc., Canada) serum IgG levels were detected. The results of the urea breath test and card test were compared. A total of 91 (61%) of the 149 patients who were admitted to hospital with epigastric pain H.pylori urea breath test were positive; 128 (86%) of the patients who were examined with the rapid cassette test were detected as positivite. In 7 (8%)of the 91 patients who were found to be positive with the urea breath test, the card test was found to be negative, and in 44 (78%) of the 58 patients who were detected negative with urea breath test, positivity was detected with the card test. In diagnosis of H.pylori, a statistically significant difference was found between the urea breath test and the rapid H. pylori cassette test. When compared with the urea breath test, the specificity, sensitivity, positive predictive and negative predictive values of the rapid H.pylori card test was found to be 21.4%, 92.3%, 65.6% and 79.1 respectively. When the results were assessed considering factors such as the possibility of a late antibody response and its persistency, as well as negative effects of antibiotic and/or proton pump inhibitors, it was thought that using the chromatographic methods in seroepidemiologic studies rather than diagnosis would be more convenient.

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