Multiple Drug Ingestion For Suicidal Purpose: Alprazolam, Citalopram, Risperidone, Oxcarbazepine And Alcohol
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https://doi.org/10.58600/eurjther.2008-14-2-1342-archKeywords:
Alprazolam, citalopram, risperidone, oxcarbazepine, alcohol, multiple drug intoxicationAbstract
Hipnotik ajanlar, antidepresan ve antipsikotik ilaçlar uykusuzluk, depresyon ve psikotik bozuklukların tedavisinde yaygın olarak kullanılmaktadır. Bu ajanlarla aşırı doz alımı giderek daha fazla bildirilmesine rağmen, şimdiye kadar alprazolam, sitalopram, risperidon, okskarbazepin ve alkol dahil olmak üzere birlikte alım vakası gösterilmemiştir. Gelişmekte olan ülkelerde bu ilaçların reçete kullanımı artmaya devam ettikçe, klinik toksisitelerini ve klinik yaklaşımlarını değerlendirmek gerekmektedir. Bu çalışmada, 20 yaşında intihar amaçlı alprazolam, sitalopram, risperidon, okskarbazepin ve alkol içeren ve destekleyici tedavi ile iyileşen aşırı doz olgusu sunulmuştur. Oda arkadaşı ve hastası tarafından bilinçlendiğinde yüksek dozda alprazolam (18 mg), sitolapram hidrobromur (80 mg), risperidon (16 mg), okskarbazepin (600 mg) ve alkol aldığı bildirildi. Standart detoksifikasyon prosedürleri ve destek tedavisi ile tedavi edildi.
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Eriksson E, Carlsson M, Nilsson C, Soderpalm B. Does alprazolam, in contrast to diazepam, activate a2 adrenoceptors involved in the regulation of rat growth hormone secretion? Life Sc. 1986;38:1491-1498.
Trenton A, Currier G, Zwemer F. Fatalities associated with therapeutic use and overdose of atypical anti psychotics. CNS Drugs. 2003;17:307-24.
Capel MM, ColbridgeMG, Henry JA. Overdose profiles of new antipsychotic agents. Int J Neu. 2000;3:51-4.
Charney DS, Woods SW, Boodman WK, Rifkin B, Kinch M, Aiken B, et al. Drug treatment of panic disorder: The comparative efficacy of imipramine, alprazolam, and trazodone. J Clin Psychiatry. 1968;47:580-586.
Kolin IS, Linet QT. Double-blind comparison of the anxiolytic efficacy of alprazolam and chlordiazepoxide hydrochloride in the chronic withdrawal period from alcohol. Curr Ther Res. 1981;26:430-439.
Fernandez F, Adams F, Holms VF. Analgesic effect of alprazolam in patients with chronic, organic pain of malignant origin. J Clin Psych. 1987;167-169.
Sellers EM, Busto U. Benzodiazepines and alcohol: Assessment of the effects and consequences of psychotropic drug interactions. J Clin Psychopharmacol. 1982;2:249-262.
Linnoila M, Stapleton JM, Lister R, Moss H, Lane E, Granger A. Effect of single doses of alprazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healty volunteers. Eur J Clin Pharmacol. 1990;39:21-28.
Palva ES, Linnoila M, Scario I, Mattila MJ. Acute and subacute effects of diazepam on psychomotor skills: Interactions with alcohol. Acta Pharmacol Toxicol. 1979;45:257-264.
Fu K, Konrad RJ, Hardy RW, Brisie RM, Robinson CA. An unusual multiple drug intoxication case involving citalopram. J Anal Toxicol. 2000;24(7):648-50.
Acri AA, Henretig FM. Effects of Risperidone in overdose. Am J Emerg Med. 1998;16:498-501.
Rothenhaeusler HB, Rothenhausler HB, Hoberl C, Ehrentrout S, Kapfhammer HP, Weber MM, et al Suicide attempt by pure citalopram overdose causing longlasting severe sinus bradycardia, hypotension and syncopes: successful therapy with a temporary pacemaker. Pharmacopsychiatry. 2000;33:150-152.
Wong ICK, Lhatoo SD. Adverse reactions to new anticonvulsant drugs. Drug Safety. 2000;23(1)35-36.
Haddad LM, Shannon MW, Winchester JF Clinical Management of poisoning and Drug Overdose 3rd Ed. WB Saunders, Philadelphia. 1998;610-618.
Omoigui S. The Anesthesia Drugs Handbook 2 nd ed. Susan M Gay. USA 1995;134-137.
Lemke KA. Ability of flumazenil, butorphanol, and naloxone to reverse the anesthetic effects of oxymorphone-diazepam in dogs. JAVMA. 1996;209:776-779.
Rajkumar AP, Jebaraj P, Tharyan P. Multi-drug overdose risperidone, ziprasidone, valproate, trihexyphenidyl, and clonazepam. JAPI. 2007;55:146-8.
Dubois D. Toxicology and overdose of atypical antipsychotic medications in children: does newer necessarily mean safer? Curr Opin Pediatr. 2005;17:227-33.
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