Angiotensin Converting Enzyme Gene Polymorphisms In Male Infertility

Sacide Pehlivan; Hüseyin Onay; Erol Tavmergen; N. Tavmergen Göker; Özgür Çoğulu

doi:10.58600/eurjther.2008-14-2-1330-arch

Authors

Sacide Pehlivan Gaziantep Üniversitesi Tıp Fakültesi Tıbbi Biyoloji AD
Hüseyin Onay Ege Üniversitesi Tıp Fakültesi, Tıbbi Genetik AD
Erol Tavmergen Ege Üniversitesi Aile Planlaması Kısırlık Araştırma ve Uygulama Merkezi
N. Tavmergen Göker Ege Üniversitesi Aile Planlaması Kısırlık Araştırma ve Uygulama Merkezi
Özgür Çoğulu Ege Üniversitesi Tıp Fakültesi, Tıbbi Genetik AD

DOI:

https://doi.org/10.58600/eurjther.2008-14-2-1330-arch

Keywords:

Infertility, ACE, Polymorphism, DNA, PCR

Abstract

The aim of this study was to investigate the frequency of Angiotensin Converting Enzyme (ACE) polymorphism in patients with oligospermia or azoospermia and to compare the frequency of polymorphism with the control group which included the men who had a child within 5 years. ACE insersion (I) / deletion (D) polymorphism was investigated at 132 men; 71 of them were diagnosed as azoospermia, 31 of them were diagnosed were oligospermia and 30 of them were healthy control. Analysis revealed that azoospermic, oligospermic and controls in terms of polymorphisms, genotype and allele frequencies, the differences were not significant and were no deviations from the Hardy-Weinberg equilibrium. The DD polymorphism ratio was found to be low (27.5%, p<0.05) in the individuals diagnosed with oligospermia in comparison to normal and azoospermic males; however, this difference was not istatistically significant and it was attributed to sampling size could have provided significant relationship.

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