Late Onset Papillon-Lefevre Syndrome (A Clinical Report)


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Authors

  • Kamile Erciyas Gaziantep Üniversitesi Diş Hekimliği Fakültesi Periodontoloji AD
  • Sacide Pehlivan Gaziantep Üniversitesi Tıp Fakültesi Tıbbi Biyoloji AD
  • Serhat İnalöz Gaziantep Üniversitesi Tıp Fakültesi Dermatoloji AD
  • Ali Fuat Erciyas Gaziantep Üniversitesi Diş Hekimliği Fakültesi Ortodonti AD
  • Tuğçe Sever Gaziantep Üniversitesi Tıp Fakültesi Tıbbi Biyoloji AD

DOI:

https://doi.org/10.58600/eurjther.2009-15-2-1308-arch

Abstract

Papillon-Lefevre syndrome is a rare autosomal recessive disorder characterized by the association of palmoplantar hyperkeratosis and premature loss of both deciduous and permanent teeth. Although there were a number of studies with respect to classical PLS patients, the number of studies on the late-onset PLS was limited. This paper reports the treatment planning of the mildly affected periodontal component of a patient with late-onset Papillon-Lefevre syndrome and in DNA by investigating cytokine and MIF genotyping. Cytokine (IL- 6, IL-10, IFN-g, TGF-B1, TNFa) genotyping was performed by the PCR- SSP method. The TNFa (-238,-857) and MIF (-173) genotyping were determined by PCR-RFLP method. These results are the first detailed genetic study data concerning the Late-Onset Papillon-Lefevre Syndrome in literature. The IL-6, IL-10, TNFa and IFN-g polymorphisms were detected as high expression while TGF-B1 was detected as intermediate expression and GC genotype in the MIF (-173) gene.

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References

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Published

2009-06-01

How to Cite

Erciyas, K., Pehlivan, S., İnalöz, S., Erciyas, A. F., & Sever, T. (2009). Late Onset Papillon-Lefevre Syndrome (A Clinical Report). European Journal of Therapeutics, 15(2), 44–48. https://doi.org/10.58600/eurjther.2009-15-2-1308-arch

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Section

Case Reports