Free DNA in Circulation and its Importance

Sacide Pehlivan; Selahattin Avcı; Tuğçe Sever; Ali Bayram; Sibel Oğuzkan Balcı

doi:10.58600/eurjther.2010-16-2-1290-arch

Authors

Sacide Pehlivan Gaziantep Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji AD.
Selahattin Avcı Gaziantep Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji AD.
Tuğçe Sever Gaziantep Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji AD.
Ali Bayram Gaziantep Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji AD.
Sibel Oğuzkan Balcı Gaziantep Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji AD.

DOI:

https://doi.org/10.58600/eurjther.2010-16-2-1290-arch

Keywords:

Cell free DNA, Apoptosis, Necrosis, Genetic diagnosis

Abstract

The cell-free, nude and double helix structured DNA, which joins circulation for reasons such as cell necrosis and programmed cell death (apoptosis) and is obtained by the purification of plazma or serum samples in the circulatory system, is called Free DNA (fDNA). Although it is advocated to have existed approximately 130 years ago, its importance has been understood better for the last 20 years, and it preserves its place among the cases in which intensive studies are made in many fields of medicine such as Hematology, Gynecology and Obstetrics, Urology, Oncology, Surgery and Neurology. In this collection, it will be intended to summarize literature information wherein it is intended to answer questions such as what Free DNA is, in which fields it is studied more intensively and whether it yields promising results in diagnosis and treatment for the future.

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