Food Allergy and Philagrine Mutation in Children with Atopic Dermatitis

Gülşah Duyuler Ayçin

doi:10.54614/eurjther.2022.21009

Authors

Gülşah Duyuler Ayçin Department of Pediatric Allergy Immunology, Adana City Training and Research Hospital, Adana, Turkey https://orcid.org/0000-0002-1050-3328

DOI:

https://doi.org/10.54614/eurjther.2022.21009

Keywords:

Child, atopy, allergy

Abstract

Objective: To determine the frequency and type of food allergy in patients having atopic dermatitis and to show the presence of mutations genetically.

Methods: Patients diagnosed as having atopic dermatitis according to the Hanifin Rajka criteria were evaluated retrospectively. Eosinophils, total immunoglobin E, milk-specific immunoglobulin E, egg-specific immunoglobulin E, wheat-specific immunoglobulin E, and filaggrin gene mutation results were recorded. Nutrient elimination was performed for 1 month in patients who were thought to have food allergy owing to skin prick test and milk-specific immunoglobulin E results. The diagnosis was confirmed through a food loading test for the patients who benefited from the elimination.

Results: Of the 66 patients included in the study, 42 (63.63%) were male. Food allergies were detected in 40 patients (60.6%). According to the Scoring of Atopic Dermatitis index, 9 out of 16 patients aged 40 years and over had food allergy and 31 out of 50 patients aged under 40 years had food allergy. There was no significant difference between the groups (P=.56). All patients included in the study were examined for filaggrin. Only 1 patient with a Scoring of Atopic Dermatitis index below 40 and milk allergy was found to have p.R501 * and c.2282-2285delCAGT mutations.

Conclusion: Atopic dermatitis food allergy was found to be 60.6%. The most common improvement was egg allergy and egg elimination. There was no difference between atopic dermatitis severity and food allergy and laboratory tests. Severe atopic dermatitis was found to be 24.2%.

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References

Boguniewicz M, Leung DYM. Atopic dermatitis. In: Adkinson NF, Bochner BS, Burks AW, et al., eds. Middleton's Allergy Principles and Practice. 8th ed. Philadelphia: Saunders Elsevier; 2014:540-564.

Cookson WO, Moffatt MF; The genetics of atopic dermatitis. Curr Opin Allergy Clin Immunol. 2002;2(5):383-387.

Sampson HA. The evaluation and management of food allergy in atopic dermatitis. Clin Dermatol. 2003;21(3):183-192.

Kato A, Fukai K,Oiso N, Hosomi N, Murakami T, Ishii M. Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population. Br J Dermatol. 2003;148(4):665-669.

Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest. 2004 ;113(5):651-657.

McGrath JA. Profilagrin, dry skin and atopic dermatitis risk: size matters. J Investigative Derma.ens. 2012 ;132:10-11.

Irvine AD, McLean WH, Leung DY. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med. 2011;365(14):1315-1327.

Worth A, Sheikh A. Food allergy and atopic eczema. Curr Opin Allergy Clin Immunol. 2010;10(3):226-230.

Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Dermatol Venerol Stockh. 1980;92:44-47.

Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology. 1993;186(1):23-31.

Yum HY, Yang HJ, Kim KW, et al. Oral food challenges in children. Korean J Pediatr. 2011;54(1):6-10.

Şengül Emeksiz ZŞ, Cavkaytar Ö, Aksoy İ, Daller Y, Soyer Ö. Food hypersensitivity in atopic dermatitis during infancy: skin prick testing for whom? Asthma Allergy Immunol. 2017;15(1):32-37.

Kwon J, Kim J, Cho S, Noh G, Lee SS. Characterization of food allergies in patients with atopic dermatitis. Nutr Res Pract. 2013;7(2):115-121.

14. Eigenmann PA, Calza AM. Diagnosis of IgE-mediated food allergy among Swiss children with atopic dermatitis.Pediatr Allergy Immunol. 2000;11(2):95-100.

Hill DJ, Hosking CS, Benedictis FM, et al. Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: an international study. Clin Exp Allergy. 2008;38;15:161-168.

Kutlu A, Aydın E, Karabacak E, et al. Relationship between atopy patch test with foods and SCORAD. Türkderm. 2013;47;16:99-102.

Beken B, Çelik V, Gökmirza P, Süt N, Yazıcıoğlu M. Food sensitization and food allergy in atopic dermatitis. Osmangazi J Med. 2019;41:405-412.

Escarrer Jaume M, Muñoz-López F. Role of aeroallergens in the etiopathogenesis of atopic dermatitis. Allergol Immunopathol (Madr). 2002;30(3):126-134.

Brown SJ, Asai Y, Cordell HJ, et al. Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J Allergy Clin Immunol. 2011;127(3):661-667.

Li M, Liu JB, Liu Q, et al. Interactions between FLG mutations and allergens in atopic dermatitis. Arch Dermatol Res. 2012;304(10):787-793.

Chauhan A, Panigrahi I, Singh M, Attri SV, Agarwal A, Singh M. Prevalence of filaggrin gene R501X mutation in Indian children with allergic diseases. Indian J Pediatr. 2020;21(8):587-590.

Giardina E, Paolillo N, Sinibaldi C, Novelli G. R501X and 2282del4 filaggrin mutations do not confer susceptibility to psoriasis and atopic dermatitis in Italian patients. Dermatology. 2008;216(1):83-84.