Retrospective and Prospective Analysis of 28 Cases Applied Prenatal Diagnostic Methods Because of Neural Tube Defect Risk

Ziya Bayraktaroğlu; Sevim Balcı

doi:10.58600/eurjther.19920301-1188

Authors

Ziya Bayraktaroğlu Gaziantep Üniversitesi Tıp Fakültesi Pediatri ABD. Yrd.Doç.Dr.
Sevim Balcı Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Prof.Dr.

DOI:

https://doi.org/10.58600/eurjther.19920301-1188

Keywords:

Prenatal diagnosis, Neural tube defect, Ultrasound, Maternal serum alpha-fetoprotein

Abstract

Prenatal diagnosis was performed in mothers delivered of an infant with a neural tube defect (NTD) previously. 23 cAses were analysed retrospectively and 5 cases in prospectively, diagnosing NTD in utero by means of determining matemal serum alpha-fetoprotein (MS-AFP) levels and ultrasound (USG). 6 cases of NID detected in utero. Ali cases of NTD demonstrated elevations in MS-AFP over 2,5 of multible of median (MOM), however, these data has been found questionable because of insuffident number of cases. it was concluded that diagnostic USG 85 % sentitive and 95 % spesific for the diagnosis of NTD in utero.

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References

Say B., Tunçbilek E., Balo S., et al: Incidence of congenital malformations in a sample of the Turkish population. Hum Hered 23:434, 1973.

Alberman E., Prevention and health promotion. Br Med Bull 42:212-216, 1986.

Leek AE., Ruoss CF., Kitau MJ., et al: Raised alpha-fetoprotein in matemal serum with anencephalic pregnancy. Lancet ii: 385-391, 1973.

Brock DJH., Bolton AE., Monghan JM.: Prenatal diagnosis of anencephaly through matemal serum alpha-fetoproteins measurements. Lancet ii:923-924, 1973.

Burton KB., Sowers SG., Nelso LH.: Matemal serum alpha-fetoprotein screening in north Carolina.Experience With more than twelve thousund pregnancies. Am J 0bstet Gynecol 146:439- 444, 1983.

Gardner S., Burton BK., Johnson AM.: Matemal serum alpha-fetoprotein screening:A report of the forsyth country. Am J 0bstet Gynecol 140:250-253, 1981.

Roberts J., Elder GH., Laurence KM., et al: The efficacy of a serum screening service for neural tube defects. The south Wales experience. Lancet ii:1315-1318, 1983.

Crandal BF., Lebherz TB., Freihube R.: Neural tube defects. Pediatr Oin North Am 25:619-629, 1978.

Ferguson Smith MA., Gibson AAM., Whitfield CK., et al: Amniocentesis and the alphafetoprotein screening programme. Lancet ii:39-40, 1979.

Weiss RR., Macri JA., Elligers K., et al: Amniotic fluid alpha-fetoprotein as a marker in prenatal diagnosis of neural tube defects. 0bstet Gynecol 47:148-150, 1976.

Macri JA., Weiss RR.: Prenatal serum alpha-fetoprotein screening for neural tube defects. 0bstet Gynecol 59:633-639, 1982.

Milunsky A., Alpert E., Meff RK.:Prenatal diagnosis of neural tube defects. Matemal serum alpha-fetoprotein screening. 0bstet Gynecol 55:60-63, 1980.

Kremkau WF. Safety and long term effects of ultrasound: What to teli your patients. Oin 0bstet Gynecol 27:269-275, 1984.

Hill LM., Breckle R., Gehrking WC.: Prenatal detection of congenital malformations b:ı:ı ultrasonography. Am J 0bstet Gynecol 151:44-50, 1985.