Investigation of the association between diabetic macular edema and retinal ischemic areas
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Keywords:Diabetic macular edema, retinal ischemi, fundus fl uorescein angiography
The present study aimed to investigate the association between diabetic macular edema (DME) and retinal ischemic areas without laser treatment in DME patients, on whom fundus fl uorescein angiography (FFA) was performed.FFA fi ndings of 180 diabetic patients were evaluated in the Eye Clinic of Adana Numune Training and Research Hospital between January 2014 and March 2015. 180 diabetic patients were divided into two groups. 108 patients with DR in whom DME was detected by FFA were classifi ed as Group 1 (DME group) and 72 patients in whom DME was not detected by FFA were classifi ed as Group 2. In particular, whether or not there were any retinal ischemic areas without laser treatment was investigated. While ischemic retina area without laser treatment was detected in 75 (69.4%) patients in Group 1 (DME group), only 27 (37.5%) patients in Group 2 were identifi ed as ischemic retina area without laser treatment. This prominent difference between the two groups were statistically signifi cant (p< 0.001). In patients in Group 1, severe non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) were determined more as compared to the other group which had no DME. In the present study, retinal ischemic areas were identifi ed to be associated with DME.
Bhagat N, Grigorian RA, Tutela A, Zarbin MA. Diabetic macular edema: pathogenesis and treatment. Surv Ophthalmol 2009;54(1):1-32.
Klein R, Klein BE, Moss SE, Cruickshanks KJ. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XV. The longterm incidence of macular edema. Ophthalmology 1995;102(1):7-16.
Early treatment diabetic retinopathy study research group. Photocoagulation for Diabetic Macular Edema. Early treatment diabetic retinopathy study report number 1. Arch Ophthalmol 1985;103(2):1796-806.
Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jample HD, Shah ST, et al. Vascular endothelial growth factor in ocular fl uid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994;331(22):1480-7.
Funatsu H, Yamashita H, Ikeda T, Mimura T, Eguchi S, Hori S. Vitreous levels of interleukin-6 and vascular endothelial growth factor are related to diabetic macular edema. Ophthalmology 2003;110(9):1690-6.
Michaelides M, Kaines A, Hamilton RD, Fraser-Bell S, Rajendram R, Quhill F, et al. A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12- month data: report 2. Ophthalmology 2010;117(6):1078-86.
Wessel MM, Nair N, Aaker GD, Ehrlich JR, D’Amico DJ, Kiss S. Peripheral retinal ischaemia, as evaluated by ultra-widefi eld fl uorescein angiography, is associated with diabetic macular oedema. Br J Ophthalmol 2012;96(5):694-8.
Takamura Y, Tomomatsu T, Matsumura T, Arimura S, Gozawa M, Takihara Y, et al. The effect of photocoagulation in ischemic areas to prevent recurrence of diabetic macular edema after intravitreal bevacizumab injection. IOVS 2014;55(8):4741-46
Early Treatment Diabetic Retinopathy Study Research Group. Grading Diabetic Retinopathy From Stereoscopic Color Fundus Photographs An Extension Of The Modifi ed Airlie House Classifi cation. ETDRS report Number 10. Ophthalmology 1991;98(5):786-806.
Early Treatment Diabetic Retinopathy Study Research Group. ETDRS Report Number: 2. Ophthalmology 1987;94(7):761-74.
Das A, McGuire PG, Rangasamy S. Diabetic macular edema: pathophysiology and novel therapeutic targets. Ophthalmology 2015;2(15):1-20.
Patel RD, Messner LV, Teitelbaum B, Michel KA, Hariprasad SM. Characterization of ischemic index using ultra-widefi eld fl uorescein angiography in patients with focal and diffuse recalcitrant diabetic macular Edema. Am J Ophthalmol 2013;155(6):1038-44.
Adamis AP, Miller JW, Bernal MT, D’Amico DJ, Folkman J, Yeo TK, et al. Increased vascular endothelial growth factor in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 1994;118(4):445-50.
Haritoglou C, Kook D, Neubauer A, Wolf A, Priglinger S, Strauss R, et al. Intravitreal bevacizumab (Avastin) therapy for persistent diffuse diabetic macular edema. Retina 2006;26(9):999-1005.
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