ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Association of red Cell Distribution width with Characteristics of Coronary Atherosclerotic Plaques as Detected by Computed Tomography Angiography
1 Department of Cardiology, Hacettepe University, School of Medicine, Ankara, Turkey  
Eur J Ther 2019; 25: 58-63
DOI: 10.5152/EurJTher.2019.830
Key Words: Coronary atherosclerotic plaque, multidetector computed tomography angiography, red cell distribution width
Abstract

 

Objective: To evaluate the relationship between red blood cell distribution width (RDW) and the severity/morphology of coronary atherosclerotic plaques (CAPs).

 

Methods: We retrospectively analyzed 572 patients without a history of coronary artery disease (CAD) in whom dual-source 64-slice computed tomography angiography (CTA) was performed due to the suspicion of CAD.

 

Results: Critical CAPs were detected in 26.9% of subjects. The RDW value was higher in patients with critical CAPs than in those without (13.63±1.28 vs. 14.31±1.58, p<0.001). Patients with any type of CAP regardless of the morphology or severity revealed enhanced RDW levels compared with those with normal coronary arteries (p<0.001). In the multinomial logistic regression analysis, RDW was found as an independent predictor for the presence of severe CAP (odds ratio (OR): 1.40, 95% confidence interval (CI): 1.20–1.63, p<0.001). RDW was also found to be associated with the presence of non-calcified plaque (OR: 1.30, 95% CI: 1.08–1.57, p=0.006) and mixed plaque morphologies (OR: 1.47, 95% CI: 1.19–1.81, p<0.001) after adjusted for other variables.

 

Conclusion: Our findings suggested that RDW as a simple, available and inexpensive biomarker was significantly associated with both the severity and vulnerable morphology of CAPs in patients undergoing coronary CTA.

 

 

How to citeAteş AH, Hazırolan T, Koçyiğit D, Yalçın MU, Gürses KM, Canpolat U, et al. Association of red Cell Distribution width with Characteristics of Coronary Atherosclerotic Plaques as Detected by Computed Tomography Angiography.  Eur J Ther 2019; 25(1): 58-63.

Key Words
Authors
All
Survey
AVES | Copyright © 2019 European Journal of Therapeutics | Latest Update: 28.05.2019