ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Relationship between Thyroid Volume and Baseline Vitamin D Levels in New-Onset Graves Disease
1 Division of Endocrinology and Metabolism Disorders, Başkent University, School of Medicine, İstanbul, Turkey  
2 Clinic of Endocrinology and Metabolism Disorders, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey  
3 Clinic of Internal Medicine, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey  
4 Clinic of Nephrology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey  
Eur J Ther 2018; 24: 173-177
DOI: 10.5152/EurJTher.2018.607
Key Words: Autoimmune disorders, 25 (OH) vitamin D, TRAb, Graves disease, thyroid volume
Abstract

Objective: Serum vitamin D is shown to be decreased and associated with higher thyroid volumes in Graves disease (GD). We aimed to investigate the relationship between thyroid volume and baseline serum vitamin D status in newly diagnosed GD patients.


Methods
: This was a single-center cross-sectional study with a total of  61 new-onset GD patients (n=61, F: 40, M: 21) who were divided into two groups, according to baseline serum vitamin D levels, as Group-1 (vitamin D <20; n: 42) and  Group-2 (vitamin D ≥20; n=19). Thyroid volume (mL) and isthmus measurements (mm) were compared between the two groups.


Results
: There was an inverse correlation between the baseline serum vitamin D levels and thyroid volume, thyroid receptor autoantibodies (TRAb), free triiodothyronine (fT3), and parathyroid hormone (PTH) levels (p=0.02, r=-0.31; p=0.005, r=-0.36; p=0.04, r=-0.26; p=0.02, r=-0.32, respectively). Thyroid volume was also correlated with serum free thyroxine (fT4), fT3, TRAb, and thyroid peroxidase autoantibodies (TPOAb; p=0.001, r=0.426; p=0.001, r=0.50; p=0.04, r=0.26; p=0.001, r=0.42, respectively). Low vitamin D and high thyroglobulin antibody (TgAb) levels were significantly associated with thyroid volume based on a regression analysis (p=0.03, odds ratio [OR]:18.7, 95% confidence interval [CI]: 1.34-260.91 and p=0.04, OR: 16.6, 95% CI: 1.07-255.64, respectively).


Conclusion
: Baseline serum vitamin D levels are inversely related with thyroid volumes, fT3, and TRAb levels  in new-onset GD. In addition to several advantages, optimization of vitamin D levels would also be beneficial in the surveillance of these patients. However, larger scale studies are required to make further suggestions.

 

 

How to citeYenidünya Yalın G, Çelik H, Cenik F, Yalın SF. Relationship between Thyroid Volume and Baseline Vitamin D Levels in New-Onset Graves Disease. Eur J Ther 2018; 24(3): 173-7.

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