ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Echocardiographic and Laboratory Findings of Turkish Children during the First Attack of Acute Rheumatic Fever
1 Clinic of Pediatric Cardiology, Adana City Training and Research Hospital, Adana, Turkey  
2 Department of Pediatric Cardiology, Afyon Health Sciences University School of Medicine Hospital, Afyon, Turkey  
3 Department of Pharmacology, Afyon Health Science University School of Medicine, Afyon, Turkey  
4 Department of Medical Biochemistry, Afyon Health Science University School of Medicine, Afyon, Turkey  
Eur J Ther 2018; 24: 77-82
DOI: 10.5152/EurJTher.2017.191
Key Words: Acute rheumatic fever, carditis, children, Doppler echocardiography
Abstract

Objective: In this study, we aim to determine demographic features and laboratory data of Turkish children who are diagnosed with acute rheumatic carditis and to evaluate echocardiographic indices of the left ventricle (LV) and right ventricle (RV) systolic-diastolic functions at the time of diagnosis.


Methods
: This is a retrospective review of 100 children who were hospitalized because of the diagnosis of acute rheumatic fever (ARF)-related acute-stage carditis and 100 healthy children who were matched with respect to age and body mass index. All subjects initially underwent detailed two-dimensional (2D), pulsed Doppler, and tissue Doppler for assessment of ventricular functions.


Results
: Internal diameter of LV, measured during end-systole, was significantly increased and the mitral annular plane systolic excursion was decreased in patients compared with those in controls (p=0.005). Although E’ velocity derived from septal mitral annulus were significantly lower, isovolumetric contraction time and myocardial performance index were increased in the carditis group compared with that in the control group. Peak early diastolic (E’), late diastolic (A’), and systolic (S’) myocardial velocities; isovolumetric contraction time; and myocardial performance index measured from the tricuspid annulus were similar in the carditis and control groups, although isovolumetric relaxation time was significantly prolonged. The carditis group had significantly lower mean corpuscular and platelet volume than the control group, although erythrocyte sedimentation rate and serum C-reactive protein levels were higher.


Conclusion
: We detected a subclinical reduction in the systolic and diastolic function of both ventricles in children with the first attack of ARF. “Pulsed” and tissue Doppler techniques in pediatric patients with ARF have an important role in assessing cardiac functions. 
 

How to cite: Çilsal E, Pektaş A, Pektaş BM, Koca BH. Echocardiographic and Laboratory Findings of Turkish Children during the First Attack of Acute Rheumatic Fever. Eur J Ther 2018; 24(2): 77-82.

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