ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Squamous cell carcinoma of the lower lip; is prophylactic neck dissection required and evaluating predictive factors influencing prognosis
1 Özel Hatem Hospital, Clinic of Ear Nose Throat, Gaziantep, Turkey  
2 Deva Hospital, Gaziantep, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2019.18040
Key Words: lower lip scc, prophylactic neck dissection, lip reconstruction

Objectives: This research is introducing our experience including a series of 87 cases of squamous cell carcinoma of the lower lip. We aimed to evaluate the efficacy of prophylactic neck dissection and determinative factors for local recurrence and regional metastasis in lower lip carcinomas.


Methods: Medical records of the 87 consecutive patients diagnosed with squamous cell carcinoma (SCC) of the lower lip were analyzed retrospectively for specific parameters at Dr.Ersin Arslan Research and Training hospital Ear Nose Throat(ENT) and Plastic & Reconstructive surgery clinic and Gaziantep University hospital ENT clinic during a period between 2011 and 2017. Patients operated previously in other centers were excluded from the study. Tumor excision with safe margins confirmed by frozen sections and supraomohyoid neck dissection was performed to all the patients involved in this study. The minimum follow-up was 12 months for all patients. The median follow-up was 23 months (ranging from 12 to 72 months).


Result: Data analysis indicated that local recurrence was significantly related to tumor size, depth and proximity of the tumor to surgical margins. Local recurrence was detected in 8(9,1 %) of 87 patients. Time from onset of disease to diagnosis, size of tumor and proximity of the tumor to lip commissure play important role in regional metastasis. Overall regional metastasis rate was found 22,9 % (20 of the 87 patients). Occult metastasis rate was found 9,1 % (8 of the 87 patients). The overall survival rate of patients with lower lip carcinoma, who underwent supraomohyoid neck dissection and excision of the tumor was 96,5 % (84 of the 87 patients).


Conclusion: Although lower lip cancers generally have a good prognosis after a proper surgical intervention, it can be life-threatening in case of neck metastasis or local recurrence. Certain factors such as tumor size, location and time interval between onset of disease and diagnosis are influencing the prognosis. Prophylactic neck dissection should be performed when the risk of cervical lymph node metastases is high in patients, especially to cases in which tumor is close to the commissure. Early detection, prophylactic neck dissection and follow-up with frequent intervals are essential for the good prognosis.

Key Words
AVES | Copyright © 2019 European Journal of Therapeutics | Latest Update: 18.09.2019