ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Investigation of relation vitamin d, parathyroid hormone, calcium serum level and insulin resistance among obese individuals
1 Department of Biochemistry Science and Technology, Gaziantep University, Institute of Natural and Applied Sciences, Gaziantep, Turkey.  
2 Department of Endocrinology and Metabolism, Gaziantep University School of Medicine, Gaziantep, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2018.507
Key Words: Vitamin D, Parathormone , Calcium, Obesity, Insuline resistance
Abstract

Objective: Several studies have shown that 25-hydroxyvitaminD, parathyroid hormone and serum calcium may play functional role with insulin resistance.

 

Method: This case control study included 60 obese individuals with impaired fasting glucose who were compared with 60 non-obese individuals with normal fasting glucose who visited the endocrinology and metabolism department. Fasting plasma glucose, fasting insulin, triglyceride, parathyroid hormone and serum 25-Hydroxyvitamin D were measured from all subjects by the morning after about 8 hours fasting using methods respect to the standard operating procedures. HOMA-IR was used for determining the insulin resistance. The statistical analysis was attained by SPSS.

 

Results: Lack of association was found between serum 25(OH)D and insulin resistance (HOMA-IR) before and after adjusting PTH, Ca and various variables either in all participants or after exclusion of participants with HOMA-IR ≤2.5 .While PTH showed a significant inverse correlation with fasting insulin (P= 0.022) and HOMA-IR (P= 0.023) after adjusting of 25(OH)D, serum Ca and various variables and exclusion of participants with HOMA-IR ≤ 2.5 .

 

Conclusion: In the present study , we did not find a relation between insulin resistance and vitamin d levels. Further studies needed for clarifying the relationship between insulin resistance and vitamin d levels.

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