ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Comparison of Treatment Outcomes in Patients with Rectal Cancer
1 Cumhuriyet University Medical School, Radiation Oncology, Sivas, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2019.354
Key Words: Rectal Cancer, Preoperative chemoradiotherapy, Postoperative chemoradiotherapy, Nonoperative chemoradiotherapy
Abstract

Aim: The aim of the present study is to evaluate survival results and chemoradiotherapy acute toxicity of patients with rectal cancer who treated with preoperative chemoradiotherapy (CRT), postoperative CRT, and non-operative CRT.

 

Method: Data of 139 patients with rectal cancer were analyzed retrospectively. However, data of 9 (6%) patients who died during and immediately after treatment and 2 (1%) patients who gave up the treatment were not used in the survival analysis.

 

Results: Postoperative CRT applied to 57 (44%) patients, preoperative CRT to 47 (37%) patients, and non-operative CRT to 24 (19%) patients. Non-operative CRT patient group was the oldest patient group (median age 70). There was a difference between the treatment groups regarding tumor localization (p<0.001), pathological stage (p<0.001), lymphovascular (LVI, p<0.004) and perineural invasion (PNI, p=0.017). While a difference determined between the groups regarding median follow-up, the patient group receiving postoperative CRT had the longest median follow-up (p<0.001). A difference determined between the groups regarding local recurrence and distant metastasis (p=0.467 and p=0.901, respectively). The three-year overall survival and disease-free survival rates were 78% and 78% for the group receiving postoperative CRT, 76% and 73% for the group receiving preoperative CRT, 48% and 41% for the group receiving non-operative CRT (p<0.001 and p<0.001, respectively). However, the difference between pre/postoperative CRT regarding overall and disease-free survival was not determined since non-operative CRT group included in survival analysis (p=0.184 and p=0.073, respectively). No difference found between three groups regarding adverse effects of chemoradiotherapy (p>0.050).

 

Conclusions: While no difference determined in pre/postoperative CRT applications regarding the incidence of local recurrence and distant metastasis, and overall and disease-free survival, and adverse effects of treatment, LVI and PNI determined in earlier pathological stage and lower frequency for the preoperative application. However, overall survival results of patients receiving non-operative CRT were worse compared to patients receiving operative CRT.

 

Cite this article as: Erdiş E, Yücel B. Comparison of Treatment Outcomes in Patients with Rectal Cancer. Eur J Ther 2019; DOI: 10.5152/EurJTher.2019.354

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