ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Can the Ratio of Calcium to Albumin Predict the Severity of Aortic Stenosis?
1 Department of Cardiology, Necmettin Erbakan University, School of Medicine, Konya, Turkey  
2 Clinic of Cardiology, Ahi Evran University, Training and Research Hospital, Kırşehir, Turkey  
3 Clinic of Cardiology, Atatürk Training and Research Hospital, Ankara, Turkey  
4 Department of Cardiology, Yıldırım Beyazıt University, School of Medicine, Ankara, Turkey  
Eur J Ther 2019; 25: 44-50
DOI: 10.5152/EurJTher.2018.761
Key Words: Albumin, aortic stenosis, calcium, calcium to albumin ratio


Objective: Aortic sclerosis is observed in 25% of the elderly population, and 2.5% of these patients have severe aortic stenosis (AS). Numerous studies have reported a relationship between the serum calcium or albumin levels and AS. The present study investigated the relationship between the calcium toalbumin ratio (CAR) and AS.


Methods: Our study included 185 patients and 108 subjects as the control group. A routine transthoracic echocardiographic evaluation and laboratory examinations were performed inall participants. The corrected serum calcium levels were calculated using the most commonly used formula: corrected calcium=measured total calcium (mg/dL) + 0.8 (4.0−serum albumin [g/dL]).


Results: The serum C-reactive protein CRP, calcium, and corrected calcium levels were significantly different between the study groups (p<0.05), and the albumin levels were significantly decreased parallel withthe AS severity (p<0.001). Also, we detected a negative correlation between the albumin and corrected calcium levels and the EuroSCORE. CAR and corrected calcium to albumin ratio (cCAR) were significantly higher in the AS group, as expected (p<0.01). In the logistic regression analysis, albumin, CRP, low-density lipoprotein LDL, theCAR, and  cCAR levels were found to be significantly and independently associated with the presence of AS (p<0.05). Moreover, in a regression analysis in the subgroup of AS only, albumin, the cCAR, and CAR were independently associated with the presence of very severe AS.


Conclusion: Our study showed an important relationship between the CAR and AS. Therefore, in clinical practice, this simple, inexpensive, and practical method may predict the severity of AS.


How to citeAlsancak Y, Sivri S, Baştuğ S, Ayhan H, Bozkurt E. Can the Ratio of Calcium to Albumin Predict the Severity of Aortic Stenosis? Eur J Ther 2019; 25(1): 44-50.

Key Words
AVES | Copyright © 2019 European Journal of Therapeutics | Latest Update: 28.05.2019