ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Evaluation of Antimicrobial Prophylaxis Use and Rate of Surgical Site Infection in Surgical Ward of Wachemo University Nigist Eleni Mohammed Memorial Hospital, Southern Ethiopia
1 Department of Pharmacy, Wachemo University School of Medicine, Hosanna, Ethiopia  
2 Institute of Ethiopian Biotechnology, Addis Ababa, Ethiopia  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2018.816
Key Words: Associated factors, surgical site infection, susceptibility, ethiopia

Objective: Surgical site infection (SSI) is the foremost infection in the overall patient population, affecting up to 66% of operated patients and with a frequency up to nine times more than in developed countries. This study aimed to determine the rate, associated factors of surgical site infection as well as on the causative agents and their antimicrobial susceptibility at the surgical ward of Wachemo University Nigist Eleni Mohamed Memorial Hospital (WUNEMMH), Southern Ethiopia.


Methods: Prospective observational study involving 255 patients that undergone a surgical procedure at WUNEMMH from January 1 to September 1, 2017.  We extracted data by direct observation from medical charts, operational and anesthesia note and Interviewer administered the semi-structured questionnaire. We collected wound specimens and processed based on standard operating procedure; disc-diffusion antibiotic susceptibility test was done. To identify factors significantly associated with SSI, the Multivariable logistic regression model was used.


Results: Forty-two patients (16.5%) developed SSIs. The most causative organism of surgical site infection were Klebsiella pneumoniae (60%).Ciprofloxacin and ceftriaxone were sensitive antibiotic. Surgery waiting time>7days, AOR=2.48 (95%CI[1.28-4.79]),P=0.007), Operation time>1hr.,AOR=2.13(95%CI[1.18-3.86],P=0.012),  and administering antibiotic  before 1 hour of operation, AOR = 5.05(95%CI[1.79-14.21),P =0.002), smoking, AOR = 8.01 (95% CI [2.15 29.84],P=0.002)were independently associated with surgical site infections.


Conclusion: The rate of SSI is relatively high. Klebsiella pneumoniae is the most causative agent for SSI. Commonly used antimicrobial agents were sensitive to organisms causing SSI at WUNEMMH

Key Words
AVES | Copyright © 2019 European Journal of Therapeutics | Latest Update: 18.09.2019