ISSN 2564-7784 | E-ISSN 2564-7040
Review
HLA-G with benefits and damages: A review
1 İzmir Katip Çelebi University, Faculty of Medicine, Department of Medical Biology and Genetics, İzmir, Turkey;Medical Sciences University, Tepecik Traning and Research Hospital, Tissue Typing Laboratory, İzmir, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2019.18063
Key Words: HLA-G, Pregnancy, Immune Tolerance, Transplantation, Cancer
Abstract

Human leucocyte antigen-G (HLA-G) is a non-classical HLA that researchers primarily focused on association with the complications of pregnancy. Recent studies about the immunomodulatory characteristics of HLA-G showed that this molecule is not only important in pregnancy but also have effects on transplantation, autoimmune diseases, cancer and infectious diseases. The restricted polymorphic nature and the disease association has also showed in various studies. In this review it was aimed to evaluate the benefits and damages of the HLA-G by considering both the expression levels and polymorphisms.

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AVES | Copyright © 2019 European Journal of Therapeutics | Latest Update: 18.09.2019