ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Outcome of Elderly Nasopharyngeal Carcinoma Patients: A Single Center Study
1 Department of Radiation Oncology, Tekirdağ State Hospital, Tekirdağ, Turkey  
2 Department of Radiation Oncology, Hacettepe University School of Medicine, Ankara, Turkey  
3 Department of Radiation Oncology, Baskent University Adana Dr. Turgut Noyan Research and Treatment Center, Adana, Turkey  
4 Department of Otorhinolaryngology, Hacettepe University School of Medicine, Ankara, Turkey  
5 Department of Medical Oncology, Hacettepe University School of Medicine, Ankara, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2019.19079
Key Words: Elderly, nasopharyngeal carcinoma, survival, chemo-radiotherapy
Abstract

 

Objective: The aim of this study is to assess efficiency of radiotherapy and evaluate outcomes of the elderly (>65 years) patients after treatments for nasopharyngeal carcinoma (NPC).

 

Methods: Between 1994 and 2012, 45 elderly patients with a diagnosis of undifferentiated nasopharyngeal carcinoma treated in our institution were evaluated retrospectively. The primary endpoint was the relation between the patients' characteristics and overall survival (OS) while progression free survival (PFS) and locoregional progression free survival (LR-PFS) and toxicity analysis were the secondary end-points.

 

Results: There were 35 male and 10 female patients with a median age of 74.2 years. At a median 64 months follow-up time, the median OS, PFS and LR-PFS were 45 months (%95 CI:5.887-84.113),34 (%95 CI: 0.0-70.504) and 45 (%95 CI: 20.092-69908), respectively. The 2, 3, and 5 year OS rates were 61.5%, 53.1%, and 50.0%, and PFS rates were 57.6%, 46.8%, and 43.7%, respectively. Patients with T3-T4 (vs.T1-2) or N2 (vs.N0-1) had significantly shorter OS (p<0.05 for each), PFS (p<0.05 for each) and LR-PFS (p<0.05 for each) outcomes, respectively which were also comfirmed in multivariate analysis (p<0.05 for each).

 

Conclusion: Our results demonstrated that the established prognostic factors including T and N stages were also important prognosticators in elderly nasopharyngeal carsinoma patients.

 

How to cite: Başaran H, Cengiz M, Yazıcı G, Özdemir Y, Süslü N, Güllü İH, et al. Outcome of Elderly Nasopharyngeal Carcinoma Patients: A Single Center Study. Eur J Ther 2019; DOI: 10.5152/EurJTher.2019.19079.

Key Words
Authors
All
Survey
AVES | Copyright © 2019 European Journal of Therapeutics | Latest Update: 28.05.2019