ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
The Relationship between Mitral Chordae Rupture and Inflammation Level and Oxidative Stress
1 Science and Health University, Adana City Training & Research Hospital, Adana, Turkey  
2 Gaziantep University, Department of Cardiology, Gaziantep, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2019.19063
Key Words: Mitral valve, chordae rupture, oxidative stress, IL-6, TNF-α

Background and aim: There are many factors associated with chorda tendinea rupture. The present study aims to investigate the role of Interleukin-6 (IL-6), total antioxidant activity (TAA), total oxidant activity (TOA) and tumor necrosis factor alpha (TNF- α) levels on the development of the mitral valve chordae tendinea rupture.


Methods: Our study consisted of 30 patients with mitral chordae rupture, 30 patients with severe rheumatic mitral regurgitation, and 20 healthy participants who were admitted to our polyclinic unit. The participants do not have a previously known comorbid disease. After transthoracic echocardiography, their diagnoses were confirmed by the transesophageal echocardiography. Plasma IL-6, TAA-TOA and TNF-α level of all patients were measured and their oxidative stress index (OSI) was calculated.


Results: Compared to the rheumatic severe mitral insufficiency patients and control group, TOA-OSI levels in the chordae rupture group were significantly higher (p=0.038 and p=0.019, respectively). The TNF-alpha levels in the rheumatic severe mitral insufficiency group were determined as statistically and significantly higher than the chordae rupture group (p=0.028).


Conclusion: We have put forth that there is a significant relationship between the chordae rupture levels and oxidative stress levels (TOA-OSI) for the first time in our study. According to the results of our study, high oxidative stress might be accepted as a risk factor for chordae rupture. In addition, it has been observed that the TNF-α level in the rheumatic severe mitral insufficiency group have been higher than those in the chordae rupture group. It seems, these data support the role of inflammation in the rheumatic severe mitral insufficiency development.


Cite this article as: Kaplan M, Yavuz F, Davutoğlu V, Yüce M, Dönmez Y, Özcan Abacıoğlu Ö. The Relationship between Mitral Chordae Rupture and Inflammation Level and Oxidative Stress. Eur J Ther 2019; DOI: 10.5152/EurJTher.2019.19063

Key Words
AVES | Copyright © 2019 European Journal of Therapeutics | Latest Update: 18.09.2019