European Journal of Therapeutics
Original Article

The Relationship between Mitral Chordae Rupture and Inflammation Level and Oxidative Stress

1.

Science and Health University, Adana City Training & Research Hospital, Adana, Turkey

2.

Department of Cardiology, Gaziantep University School of Medicine, Gaziantep, Turkey

Eur J Ther 2020; 26: 117-121
DOI: 10.5152/EurJTher.2019.19063
Read: 119 Downloads: 98 Published: 29 June 2020

Objective: There are many factors associated with chorda tendinea rupture. The present study aims to investigate the role of Interleukin-6 (IL-6), total antioxidant activity (TAA), total oxidant activity (TOA) and tumor necrosis factor alpha (TNF- α) levels on the development of the mitral valve chordae tendinea rupture.

Methods: Our study consisted of 30 patients with mitral chordae rupture, 30 patients with severe rheumatic mitral regurgitation, and 20 healthy participants who were admitted to our polyclinic unit.  The participants do not have a previously known comorbid disease. After transthoracic echocardiography, their diagnoses were confirmed by the transesophageal echocardiography. Plasma IL-6, TAA-TOA and TNF-α level of all patients were measured and their oxidative stress index (OSI) was calculated.

Results: Compared to the rheumatic severe mitral insufficiency patients and control group, TOA-OSI levels in the chordae rupture group were significantly higher (p=0.038 and p=0.019, respectively). The TNF-alpha levels in the rheumatic severe mitral insufficiency group were determined as statistically and significantly higher than the chordae rupture group (p=0.028).

Conclusion: We have put forth that there is a significant relationship between the chordae rupture levels and oxidative stress levels (TOA-OSI) for the first time in our study. According to the results of our study, high oxidative stress might be accepted as a risk factor for chordae rupture. In addition, it has been observed that the TNF-α level in the rheumatic severe mitral insufficiency group have been higher than those in the chordae rupture group. It seems, these data support the role of inflammation in the rheumatic severe mitral insufficiency development.

How to cite: Kaplan M, Yavuz F, Davutoğlu V, Yüce M, Dönmez Y, Özcan Abacıoğlu Ö. The Relationship between Mitral Chordae Rupture and Inflammation Level and Oxidative Stress. Eur J Ther 2020; 26(2): 117-121.

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EISSN 2564-7040