European Journal of Therapeutics
Original Article

THE RELATIONSHIP BETWEEN CD 74 LEVELS, MACROPHAGE MIGRATION INHIBITORY FACTOR GENE POLYMORPHISM AND CLINICAL FEATURES IN PATIENTS WITH ANKYLOSING SPONDYLITIS

1.

Gaziantep University, Faculty of Medicine, Department of Physical Medicine and Rehabilitaton, Gaziantep, Turkey

2.

Istanbul University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey

3.

Gaziantep University, Faculty of Medicine, Department of Medical Microbiology, Gaziantep, Turkey

Eur J Ther 1; 1: 0-0
DOI: 10.5152/EurJTher.2019.19048
Read: 43 Downloads: 9 Published: 03 September 2019

Abstract

Objective: In this study, the primary objective was to compare CD 74 antigen levels between patients with ankylosing spondylitis (AS) and healthy controls. The secondary objective was to investigate the distribution of Macrophage Migration Inhibitory Factor (MIF) 173 G/C polymorphisms in AS patients and a control group. Finally, it was also aimed to reveal the presence of a relationship between CD 74 antigen levels and MIF 173 G/C polymorphism.

 

Materials and Methods: 82 healthy blood donors and 79 AS patients were enrolled in this study. MIF 173 G/C polymorphism and CD 74 levels were investigated in the patient and control groups using the ELISA method. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Radiology Index (BASRI), Visual Analogue Scale (VAS) and Ankylosing Spondylitis Quality of Life (ASQoL) scores were calculated and recorded.

 

Results: There was no significant difference between the patient and control groups in terms of age, gender, and body mass index. The median CD74 level of the patient group was 1.17 (0.93-2.1), which was significantly lower than that of the control group, i.e. 2.16 (1.6-4.41). There was no correlation between CD 74 antigen levels and BASDAI, BASMI, BASFI, BASRI, VAS and ASQoL scores. The number of patients who had the C allele was higher among the patients with AS in comparison to the control group; however, the difference was not statistically significant (p>0.05). There was no correlation between genotypes and BASDAI, BASMI, BASFI, BASRI, VAS and ASQoL scores (p>0.05). Comparison of the median CD74 levels of the individuals in the patient group according to their HLA-B27 status and genotypes did not reveal any statistically significant difference.

 

Conclusion: The CD74 antigen levels of the patients with AS were significantly lower compared to the control group. This implies that CD 74 is a parameter that can be used in the diagnosis of AS. Although the C allele among the MIF 173 G/C polymorphisms was more frequently observed in the patient group, the difference was not statistically significant. Moreover, there was no significant relationship between CD 74 antigen levels and polymorphisms.

 

How to cite: Akaltun MS, Pehlivan S, Karslıgil T, Altındağ Ö, Aydeniz A, Gür A, et al. THE RELATIONSHIP BETWEEN CD 74 LEVELS, MACROPHAGE MIGRATION INHIBITORY FACTOR GENE POLYMORPHISM AND CLINICAL FEATURES IN PATIENTS WITH ANKYLOSING SPONDYLITIS. Eur J Ther 2019; DOI: 10.5152/EurJTher.2019.19048

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ISSN2564-7784 EISSN 2564-7040