European Journal of Therapeutics
Original Article

The levels of HbA1c in patients with thyroid dysfunction

1.

Numune Training and Research Hospital, Internal Medicine, Ankara, Turkey

2.

Numune Training and Research Hospital, Family Health Clinics, Ankara, Turkey

3.

Atatürk Training and Research Hospital, Endocrinology and Metabolism Diseases, Ankara,Turkey

Eur J Ther 2015; 21: 5-8
DOI: 10.5455/GMJ-30-161185
Read: 554 Downloads: 228 Published: 03 September 2019

Abstract

Thyroid hormones increase the hepatic glyconeogenesis, glycogenolysis and the absorption of glucose. Glucose intolerance is common in thyroid dysfunction. HbA1c is the most important determinant of long term glysemic status in diabetic patients. HbA1c is affected from various factors. In this study we evaluated the relation between thyroid function tests and HbA1c in non-diabetic patients with thyroid dysfunction. Non-diabetic 43 patients with hyperthyroidism, 20 patients with hypothyroidism and for control group 29 euthyroid patients which appealed to Ankara Numune Training and Research Hospital Internal Outpatient Clinic between June 2008 and January 2009 were recruited to this study. Fasting blood sugar, urea, creatinine, hemoglobine, HbA1c, TSH, FT3, FT4 and albumine levels of all of the patients that recruited to study were determined. There was no statistically significant difference for the mean age (p=0.271) and gender distribution (p=0.23) in the cases of hyperthyroidism, hypothyroidism and euthyroid controls. HbA1c levels were significantly higher in hyperthyroid group when compared to hypothyroid and euthyroid groups (p<0,001). Fasting blood glucose levels were found significantly higher in hyper thyroid group than hypothyroid and euthyroid groups (p=0.018). A positive correlation was revealed between the increasing age and HbA1c levels. A statistically significant difference was found in the levels of HbA1c values in patients with hyperthyroidism according to euthyroid and hypothyroid patients and this finding is in compliance with the results of current literature. This makes us to think that here is a relation between insulin resistance and hyperthyroidism. Therefore, it is suggested that monitorisation of blood glucose levels regularly is useful for the early diagnose of type II diabetes mellitus in patients with hyperthyroidism, both during the therapy and post treatment period.

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EISSN 2564-7040