European Journal of Therapeutics
Original Research

The Importance of Thiol/Disulfide Homeostasis-and Ischemia-Modified Albumin Levels in Acute Coronary Syndrome and Their Relationship with Angiographic Scoring Systems

1.

Department of Cardiology, Biruni University School of Medicine, İstanbul, Turkey

2.

Department of Biochemistry, Biruni University School of Medicine, İstanbul, Turkey

3.

Department of Biochemistry, Yildirim Beyazit University School of Medicine, Ankara, Turkey

4.

Department of Emergency Medicine, Biruni University School of Medicine, İstanbul, Turkey

5.

Department of Internal Medicine, Biruni University School of Medicine, İstanbul, Turkey

Eur J Ther 2020; 26: 291-297
DOI: 10.5152/eurjther.2020.20021
Read: 170 Downloads: 96 Published: 01 December 2020

Objective: The objective of this study was to investigate the differences in thiol/disulfide homeostasis- and ischemia-modified albumin (IMA) levels that are known to be associated with oxidative damage in patients with acute coronary syndrome between ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction/unstable angina pectoris (NSTEMI/USAP) groups and their relationships with angiographic scoring systems.

Methods: A total of 142 patients were included in this study, with 49 in group 1 (STEMI) and 93 in group 2 (NSTEMI/USAP). Thiol/disulfide homeostasis was determined using a recently developed novel method. We investigated whether thiol/disulfide homeostasis and parameters such as IMA, troponin I, and creatine kinase MB fraction levels were associated with Gensini, and Syntax I and II scores, which are angiographic scoring systems.

Results: The native and total thiol levels were found to be statistically significantly lower in the STEMI group than in the NSTEMI/USAP group (both, p < 0.05). The serum IMA levels were statistically significantly higher in group 1 (0.59±0.12 vs 0.46±0.23 absorbance units, p<0.05). A significant positive correlation was found between the IMA and peak troponin I levels.

Conclusion: Thiol/disulfide homeostasis was shifted in favor of disulfide in the STEMI group, indicating a significant correlation between increased myocardial damage and disulfide. Similarly, the significantly higher IMA levels and positive correlation between IMA and peak troponin I in the STEMI group indicate its vulnerability in the infarcted myocardium area in addition to its vulnerability known in ischemia.

How to cite: Ermiş E, Hanikoğlu F, Uçar H, Allahverdiyev S, Yıldırım E, Neşelioğlu S, et al. The Importance of Thiol/Disulfide Homeostasis-and Ischemia-Modified Albumin Levels in Acute Coronary Syndrome and Their Relationship with Angiographic Scoring Systems. Eur J Ther 2020; 26(4): 291-7.

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