European Journal of Therapeutics
Original Article

The Effect of Epinephrine Administration on Return of Spontaneous Circulation (ROSC) and One-Month Mortality in Cardiopulmonary Arrest Patients

1.

Emergency Department of Nizip State Hospital, Gaziantep /Turkey

2.

Emergency Department of Gaziantep University, Gaziantep /Turkey

3.

Hasan Kalyoncu University, Gaziantep /Turkey

4.

Emergency Department of Düzce University, Düzce /Turkey

5.

Emergency Department of Şehitkamil State Hospital, Gaziantep /Turkey

6.

Emergency Department of Kilis State Hospital, Kilis /Turkey

7.

Emergency Department of Söke Fehime Faik Kocagöz State Hospital, Aydın /Turkey

8.

Biostatistics Department of Gaziantep University, Gaziantep/TURKEY

Eur J Ther 1; 1: -
DOI: 10.5152/EurJTher.2020.190124
Read: 86 Downloads: 55 Published: 13 July 2020

Objective: Determination of the Effect of Epinephrine on Return of Spontaneous Circulation (ROSC) and One Month Mortality in Cardiopulmonary Resuscitation (CPR).

Methods: The study was conducted between August 1, 2016 and May 31, 2017. Witnessed cases of In-Emergency Department Cardiopulmonary Arrest (IEDCA) and Out-of-Hospital Cardiopulmonary Arrest (OHCA) ≥18-years-old were included in the study. The patients were divided into two groups: the adrenaline group (Group 1), and the non-adrenaline group (Group 2). ROSC and one-month mortality were investigated.
 

Results: 183 patients (50.3% male, 49.7% female; mean age 64.2 ±16.8) were included in the study. The ratio of IEDCA and OHCA cases were 25.1% and 74.9%, respectively. Epinephrine was administered to 100 (54.6%) patients (Group 1). The rate of the initial rhythms were shockable rhythms (VF, pulseless VT) 15.9% (n=29) and non-shockable rhythms (Asystole, PEA) 84.1% (n=154). ROSC and one-month mortality rate were 24% (n=44), 72.8% (n=36) respectively. The one-month mortality rates of the Group 1 30% (IEDCA) and 70% (OHCA) and Group 2 were 43.8% and 56.2%, respectively (p=0.0231). The ROSC and one-month mortality rates of Group 1 and Group 2 cases whose initial rhythm was a shockable rhythm were 26.6% and 50% vs. 42.8% and 66.6%, respectively.
 

Conclusion: In this study, no significant difference was detected in terms of obtaining ROSC between the shockable rhythm and ROSC in the IEDCA and OHCA (p=0.963; 0.141, respectively). The effect of administering epinephrine to IEDCA and OHCA patients in which ROSC was obtained on one-month mortality was not statistically significant (p>0.05).

You may cite this article as: Sabak M, Al B, Oktay M, Zengin S, Boğan M, Gümüşboğa H, et al. The Effect of Epinephrine Administration on Return of Spontaneous Circulation (ROSC) and One-Month Mortality in Cardiopulmonary Arrest Patients. Eur J Ther 2020; DOI: 10.5152/EurJTher.2020.190124 [Epub Ahead of Print]

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