European Journal of Therapeutics
Original Article

The Effect of Epinephrine Administration on Return of Spontaneous Circulation (ROSC) and One-Month Mortality in Cardiopulmonary Arrest Patients

1.

Department of Emergency, Nizip State Hospital, Gaziantep, Turkey

2.

Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey

3.

Hasan Kalyoncu University, Gaziantep, Turkey

4.

Department of Emergency Medicine, Düzce University School of Medicine, Düzce, Turkey

5.

Emergency Department of Şehitkamil State Hospital, Gaziantep /Turkey

6.

Department of Emergency Medicine, Kilis State Hospital, Kilis, Turkey

7.

Department of Emergency, Söke Fehime Faik Kocagöz State Hospital, Aydın, Turkey

8.

Department of Biostatistics, Gaziantep University School of Medicine, Gaziantep, Turkey

Eur J Ther 1; 1: -
DOI: 10.5152/EurJTher.2020.19124
Read: 91 Downloads: 46 Published: 23 March 2020

Objective: Determination of the Effect of Epinephrine on Return of Spontaneous Circulation (ROSC) and One Month Mortality in Cardiopulmonary Resuscitation (CPR).

Methods: The study was conducted between August 1, 2016 and May 31, 2017. Witnessed cases of In-Emergency Department Cardiopulmonary Arrest (IEDCA) and Out-of-Hospital Cardiopulmonary Arrest (OHCA) ≥18-years-old were included in the study. The patients were divided into two groups: the adrenaline group (Group 1), and the non-adrenaline group (Group 2).  ROSC and one-month mortality were investigated.

Results: 183 patients (50.3% male, 49.7% female; mean age 64.2 ±16.8) were included in the study. The ratio of IEDCA and OHCA cases were 25.1% and 74.9%, respectively. Epinephrine was administered to 100 (54.6%) patients (Group 1). The rate of the initial rhythms were shockable rhythms (VF, pulseless VT) 15.9% (n=29) and non-shockable rhythms (Asystole, PEA) 84.1% (n=154). ROSC and one-month mortality rate were 24% (n=44), 72.8% (n=36) respectively. The one-month mortality rates of the Group 1 30% (IEDCA) and 70% (OHCA) and Group 2 were 43.8% and 56.2%, respectively (p=0.0231). The ROSC and one-month mortality rates of Group 1 and Group 2 cases whose initial rhythm was a shockable rhythm were 26.6% and 50% vs. 42.8% and 66.6%, respectively.

Conclusion: In this study, no significant difference was detected in terms of obtaining ROSC between the shockable rhythm and ROSC in the IEDCA and OHCA (p=0.963; 0.141, respectively). The effect of administering epinephrine to IEDCA and OHCA patients in which ROSC was obtained on one-month mortality was not statistically significant (p>0.05).

How to cite: Sabak M, Al B, Oktay M, Zengin S, Boğan M, Gümüşboğa H, et al. The Effect of Epinephrine Administration on Return of Spontaneous Circulation (ROSC) and One-Month Mortality in Cardiopulmonary Arrest Patients. Eur J Ther 2020; DOI: 10.5152/EurJTher.2020.19124

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ISSN2564-7784 EISSN 2564-7040