European Journal of Therapeutics
Original Article

Serum Adropin Level in Patients with Isolated Coronary Artery Ectasia

1.

University of Health Sciences, Adana Health Practice and Research Center, Adana, Turkey

Eur J Ther 2020; 26: 178-182
DOI: 10.5152/eurjther.2020.19119
Read: 69 Downloads: 66 Published: 22 September 2020

Objective: Isolated coronary artery ectasia (iCAE) is characterized by localized or diffuse dilatation of the coronary arteries, and the exact mechanism underlying iCAE is unclear. However, endothelial dysfunction is related to iCAE. Adropin has a regulatory effect in the coronary artery endothelium. This study aimed to determine the relationship of adropin level to iCAE.

Methods: Fifty patients with iCAE and 32 age- and sex-matched control subjects with normal coronary angiography (CAG) findings were selected from 4546 patients who underwent CAG between July 2019 and October 2019. Blood sample for adropin analysis were collected just before CAG.

Results: No significant difference was found between groups in terms of baseline characteristics and laboratory parameters. The mean adropin level in patients with iCAE was significantly lower than that in control subjects (0.33±0.35 vs. 0.55±0.35 ng/mL, p<0.001). In receiver operating characteristic analysis, the cut-off value of adropin ≤0.341 had 76.0% sensitivity and 84.37% specificity for predicting iCAE (area under the curve: 0.839, p<0.001). Multivariate analysis included age, left ventricular ejection fraction, and adropin level, which showed that adropin (per 1 ng/dL decrease) (odds ratio: 0.973 [0.956–0.990]; p=0.002) was independently associated with iCAE.

Conclusion: The present study showed that adropin level is significantly lower in patients with iCAE patients and is independently associated with iCAE.

How to cite: Küçükosmanoğlu M, Kaplan M, Yavuz F. Serum Adropin Level in Patients with Isolated Coronary Artery. Eur J Ther 2020; 26(3): 178-82.

Files
EISSN 2564-7040