European Journal of Therapeutics
Original Article

Radioprotective Effects of Propolis and Caffeic acid Phenethyl Ester on the Tongue-Tissues of Total-Head Irradiated Rats

1.

Department of Medical Biochemistry, Gaziantep University School of Medicine, Gaziantep, Turkey

2.

Division of Biochemistry, Harran University, College of Health, Şanlıurfa, Turkey

3.

Clinic of Otolaryngology, Bitlis State Hospital, Bitlis, Turkey

4.

Department of Otolaryngology, Gaziantep University School of Medicine, Gaziantep, Turkey

5.

Gaziantep University School of Medicine, Gaziantep, Turkey

Eur J Ther 2020; 26: 202-207
DOI: 10.5152/EurJTher.2020.19047
Read: 72 Downloads: 65 Published: 13 July 2020

Objective: This study aimed to investigate the radioprotective effects of propolis and caffeic acid phenethyl ester (CAPE) against radiation-induced damage in the tongue-tissues of rats exposed to total cranial gamma irradiation.

Methods: Fifty-four Sprague-Dawley rats were randomly divided into six groups. An appropriate control group was also studied. The animals were euthanized on day 10, and tongue-tissues were collected for evaluating biochemical oxidative parameters.

Results: Lipid hydroperoxides (LOOH), total oxidant status (TOS), oxidative stress index (OSI) levels and xanthine oxidase (XO) activity, and markers of oxidative stress were significantly higher, while paraoxonase (PON) activity was significantly lower for irradiated rats (IR) group compared to the other groups. When LOOH, TOS, OSI values, and XO activity in the propolis+IR and CAPE+IR groups were evaluated, there was no statistically significant difference between those ones and all control groups. In terms of the total -SH levels, the propolis+IR group was found to be significantly higher than all other groups. There was no significant difference in arylesterase (ARE) activity, ceruloplasmin (Cp) levels.

Conclusion: Propolis and CAPE reduce oxidative stress and have antioxidant effects that may be useful agents of ionizing radiation-induced tissue damage.

How to cite: Altay H, Demir E, Binici H, Aytac İ, Taysı ME, Taysı S. Radioprotective Effects of Propolis and Caffeic acid phenethyl ester on the Tongue-Tissues of Total-Head Irradiated Rats. Eur J Ther 2020; 26(3): 202-7.

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EISSN 2564-7040