European Journal of Therapeutics
Original Article

Investigation of relation vitamin d, parathyroid hormone, calcium serum level and insulin resistance among obese individuals


Department of Biochemistry Science and Technology, Gaziantep University, Institute of Natural and Applied Sciences, Gaziantep, Turkey


Department of Endocrinology and Metabolism, Gaziantep University School of Medicine, Gaziantep, Turkey

Eur J Ther 1; 1: -
DOI: 10.5152/EurJTher.2018.507
Read: 36 Downloads: 7 Published: 26 November 2019

Objective: Several studies have shown that 25-hydroxyvitaminD, parathyroid hormone and serum calcium may play functional role with insulin resistance.

Method: This case control study included 60 obese individuals with impaired fasting glucose who were compared with 60 non-obese individuals with normal fasting glucose who visited the endocrinology and metabolism department. Fasting plasma glucose, fasting insulin, triglyceride, parathyroid hormone and serum 25-Hydroxyvitamin D were measured from all subjects by the morning after about 8 hours fasting using methods respect to the standard operating procedures. HOMA-IR was used for determining the insulin resistance. The statistical analysis was attained by SPSS.

Results: Lack of association was found between serum 25(OH)D and insulin resistance (HOMAIR) before and after adjusting PTH, Ca and various variables either in all participants or after exclusion of participants with HOMA-IR ≤2.5 .While PTH showed a significant inverse correlation with fasting insulin (P= 0.022) and HOMA-IR (P= 0.023) after adjusting of 25(OH)D, serum Ca and various variables and exclusion of participants with HOMA-IR ≤ 2.5 .

Conclusion: In the present study , we did not find a relation between insulin resistance and vitamin d levels. Further studies needed for clarifying the relationship between insulin resistance and vitamin d levels.

ISSN2564-7784 EISSN 2564-7040