European Journal of Therapeutics
Original Article



Department of Medical Microbiology Gaziantep University School of Medicine, Gaziantep, Turkey

Eur J Ther 1; 1: -
DOI: 10.5152/ EurJTher.2020.19059
Keywords : Garlic, antifungal, fungi, Candida
Read: 211 Downloads: 137 Published: 13 July 2020

Objectives: Garlic (Allium sativum) is a plant that is easy to find and is claimed to have antimicrobial properties. The aim of this study was to investigate the antifungal effect of natural garlic juice on different fungal isolates.

Methods: Garlic bulbs were obtained from market, aseptically cut cross-sectional into slices and the juice was obtained via sterilized electric mincer. First, susceptibility screening test was performed by slices and juice for Candida, Epicoccum, Fusarium, Epidermophyton, Trichophyton, Aspergillus and Penicillium genera. Sabouraud dextrose agar (SDA) media were inoculated with fungal isolates. Circular wells were drilled in the center of SDA and 270 microliters of garlic juice were added to these wells. After incubation, inhibition zones were evaluated. Dilution test was performed for the most susceptible isolate. Increasing dilutions of garlic juice from 1/2 to 1/1024 were added to the wells which were drilled on Mueller Hinton agar and the inhibition zone diameters were measured after incubation.

Results: All isolates were inhibited by garlic juice. In the dilution test for Candida albicans, an inhibition zone which is larger than 25 mm was observed up to the dilution of 1/128. After the dilution of 1/256, inhibition zone gradually got smaller and no inhibition was observed at 1/1024 dilution.

Conclusion: Natural garlic juice was effective in all isolates. Most significant antifungal effect was observed against Candida albicans isolate. In underdeveloped areas where access to healthcare and medicine is difficult, garlic juice may be an inexpensive and easily accessible alternative to classical antifungal drugs.


You may cite this article as: Balach O, Gazel D, Ekşi F, Zer Y, Karslıgil T, Al Azzawi S. In Vitro Effects Of Natural Garlic Juice On Some Fungal Strains. Eur J Ther 2020; DOI: 10.5152/ EurJTher.2020.19059 [Epub Ahead of Print]

EISSN 2564-7040