European Journal of Therapeutics
Original Article

Ferritin Levels in Serum and Saliva of Oral Cancer and Oral Potentially Malignant Disorders


Department of Oral Medicine and Radiology, Yenepoya University, Yenepoya Dental College, Mangalore, Karnataka, India


Department of Oral Medicine and Radiology, NITTE University, AB Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India


Department of Oral Medicine Radiology and Special Care Dentistry, Saveetha Dental College & Hospitals, Chennai, Tamil Nadu, India


Department of Biotechnology Engineering, Visvesvaraya Technology University, Nitte Mahalinga Adyanthaya Memorial Institute of Technology, Karnataka, India

Eur J Ther 2022; 28: 109-114
DOI: 10.54614/eurjther.2021.0048
Read: 273 Downloads: 150 Published: 20 June 2022

Objective: Oral cancer remains a substantial health burden worldwide despite creditable developments in its prevention, detection, and treatment. The early detection of oral cancer offers high chances of survival and improves response to therapy making overall healthcare affordable. The aim and objective of this study were to compare and correlate serum and saliva ferritin levels in healthy subjects, oral potentially malignant disorders, and subjects with oral cancer and to assess the role of saliva as a valuable diagnostic tool.

Methods: Totally 30 participants each in 3 groups comprising healthy subjects, oral potentially malignant disorders, and oral cancer constituted the sample size. Enzyme-linked immunosorbent assay method was employed for serum and saliva ferritin levels.

Results: The respective mean serum ferritin and saliva ferritin levels were increased significantly in subjects with oral cancer (296.62 ± 82.54 ng/mL and 80.44 ± 12.94 ng/mL, respectively) and decreased significantly in oral potentially malignant disorders (69.83 ± 17.39 ng/mL and 17.49 ± 5.40 ng/mL, respectively) with a highly significant P <.001 when compared to that of healthy subjects, (116.15 ± 21.19 ng/mL and 38.47 ± 8.08 ng/mL), P <.001. All the 3 groups had a significant positive correlation between serum and saliva ferritin levels; healthy controls (r = 0.622), oral potentially malignant disorders (r = 0.878), and oral cancer (r = 0.668).

Conclusion: The encouraging results of the present study demonstrate the potential involvement of ferritin in the pathogenesis of oral potentially malignant disorders and oral cancer. Further, the study favors saliva, as a reliable and non-invasive diagnostic tool providing a cost-effective approach for screening large populations.

Cite this article as: Buch SA, Babu SG, Castelino RL, Pillai DS, Bhat S, Devi UH. Ferritin levels in serum and saliva of oral cancer and oral potentially malignant disorders. Eur J Ther. 2022;28(2):109-114.

EISSN 2564-7040