European Journal of Therapeutics
Original Research

Estimation of Salivary and Tissue Nitric Oxide Levels in Oral Squamous Cell Carcinoma: A Biochemical Study

1.

Ivory Dental Clinic, Bangkok, Thailand

2.

Department of Oral Medicine and Radiology, Nitte University, A B Shetty Memorial Institute of Dental Sciences, Mangalore, India

3.

Department of forensic medicine and toxicology, Manipal University School of Medicine, Manipal, India

Eur J Ther 2021; 27: 26-31
DOI: 10.5152/eurjther.2021.20039
Read: 183 Downloads: 27 Published: 30 July 2020

Objective: The study was conducted to estimate the salivary and tissue nitric oxide (NO) levels in healthy individuals and subjects with squamous cell carcinoma of the oral cavity. 

Methods: In this study, the salivary and tissue NO levels were estimated in 20 healthy subjects and 20 patients with oral squamous cell carcinoma (OSCC). 

Results: The mean salivary NO levels in Group I (control group) was 78.59 µM/L (standard deviation=5.91608), while the mean salivary NO levels of Group II (study group) were 115.6765 µM/L (standard deviation=0.9431). The mean tissue NO levels in Group I (control group) was 87.6315 µM/L (standard deviation=1.91631), while the mean tissue NO of Group II (study group) was 172.376 µM/L (standard deviation=0.84774.

Conclusion: Our results illustrated that the increase in the NO levels in the saliva is positively correlated with the NO level in tissues; hence, salivary NO level can be used as a potential diagnostic biomarker in OSCC.

How to cite: Ghosh R, Castelino RL, Babu SG, Banerjee B. Estimation of Salivary and Tissue Nitric Oxide Levels in Oral Squamous Cell Carcinoma: A Biochemical Study. Eur J Ther 2021; 27(1): 26-31.

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EISSN 2564-7040