European Journal of Therapeutics
Original Article

Effect of Statin Therapy in Tpe-Interval and Tpe/Qtc Ratio in Patients with Familial Hypercholesterolemia

1.

Department of Cardiology, Health Sciences University, Adana Research and Training Hospital, Adana, Turkey

2.

Department of Cardiology, Health Sciences University, Yıldırım Beyazıt Dışkapı Research and Training Hospital, Ankara, Turkey

3.

Department of Cardiology, Health Sciences University, Mehmet Akif İnan Research and Training Hospital, Şanlıurfa, Turkey

4.

Department of Cardiology, Gaziantep University School of Medicine, Gaziantep, Turkey

5.

Department of Cardiology, Ege University School of Medicine, İzmir, Turkey

Eur J Ther 2020; 26: 165-171
DOI: 10.5152/EurJTher.2020.19018
Read: 53 Downloads: 80 Published: 30 July 2020

Objectives: Studies have shown that hypercholesterolemia can induce ventricular vulnerability to fibrillation and statin therapy exerts antiarrhythmic effects. In present study, we investigated the relationship between arrhytymogenic substrate and familial hypercholesterolemia (FH) with regard to statin therapy.

Methods: We evaluated 46 statin naïve patients (41±12years) with FH, and 46 healthy subjects   (40±8years) prospectively.   Electrocardiography (ECG)   of patients were compared before and after six months of intensive statin therapy and with control groups. The ECG parameters were calculated by two experience cardiologists who blinded to each others.

Results: There  were no significant differences between groups baseline characteristics. Total  cholesterol (343±49 mg/dL vs.  161±12mg/dL; P<0.001), and LDL-C (260±42 vs. 95±13; p<0.001) levels were significantly higher in FH group.  After statin therapy, both total cholesterol (343±49 vs. 206±45; p<0.001) and LDL-C (260±42 vs. 138±40; p<0.001) levels were decreased. Both mean baseline Tpe-interval (90.7±9.3ms vs. 77.6±7.3ms; p<0.001) and Tpe/QTc ratio (0.219±0.02 vs. 0.193 ± 0.01; p<0.001) were significantly  higher in FH  group  than control subjects. After statin  therapy, Tpe-interval (90.7±9.3ms vs. 81.3±8.3ms; p<0.001) and Tpe/QTc ratio (0.219±0.02 vs. 0.201±0.02; p<0.001)  were  significantly  decreased.  Compared  to  the  control  group,  TPe-interval (81.3±8.3ms   vs.   77.6±7.3ms;   p=0.027)   and  TPe/QTc   (0.206±0.02   vs. 0.193±0.01; p=0.021) ratio remained higher in FH patients after statin therapy. There was a strong and positive  correlation  between  basal  LDL-C  and  Tpe-interval  (r=0.740;  p<0.001)  and Tpe/QTc ratio (r=0.597; p<0.001)

Conclusions: We showed that TPe-interval, and TPe/QTc ratio on ECG were significantly prolonged in FH patients and significantly improved with intense statin therapy by lowering LDL-C.

How to cite: Küçükosmanoğlu M, Kılıç S, Saraçoğlu E, Çekici Y, Vuruşkan E, Kayıkcıoğlu M. Effect of Statin Therapyin Tpe-Interval and Tpe/QTc Ratio in Patients with Familial Hypercholesterolemia. Eur J Ther 2020; 26(3): 165-71.

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