European Journal of Therapeutics
Original Research

Can Exercise Ameliorate Memory Impairment via PPAR Gamma Activation in Rats Fed A High-Fat Diet?

1.

Department of Biophysics, Gaziantep University School of Medicine, Gaziantep, Turkey

2.

Department of Medical Biology, Gaziantep University School of Medicine, Gaziantep, Turkey

3.

Department of Internal Medicine, Division of Endocrinology, Gaziantep University School of Medicine, Gaziantep, Turkey

Eur J Ther 2020; 26: 275-281
DOI: 10.5152/eurjther.2020.20017
Read: 127 Downloads: 89 Published: 01 December 2020

Objective: This study aimed at determining the molecular effects of exercise on obesity treatment and cognitive impairment by examining the relationship between exercise (one of the non-pharmacological approaches) and PPAR-γ.

Methods: We classified 32 rats into four experimental groups: random control (C), obese (Ob), control exercise group (C+Ex), and obese exercise (Ob+Ex). The experimental groups were fed with a high-fat diet (45% fat) and standard rodent chow. The exercise program commenced after obesity diagnosis (30 min/day) and continued until the end of the study. At the end of the study, all rats underwent a learning–memory test in a Morris water tank, and the hippocampus of all rats were removed under anesthesia to study the PPAR gamma gene expression level.

Results: The escape latency was significantly different between the exercise groups and non-exercise groups (p<0.05). Molecular analysis revealed an increase in PPAR-γ gene expression levels in the exercise groups compared with that observed in the non-exercise groups, but no significant difference was found when comparing the gene expression levels between the groups (p>0.05).

Conclusion: PPAR-γ gene expression levels were upregulated in the exercise groups. In addition, the exercise groups performed better with regards to cognitive functions. This result provides a clue about the impact of exercise on the molecular pathway with respect to performance differences in cognitive function due to obesity.

How to cite: Yılmaz İ, Demirel C, Balcı SO, Akarsu E. Can Exercise Ameliorate Memory Impairment via PPAR Gamma Activation in Rats Fed A High-Fat Diet? Eur J Ther 2020; 26(4): 275-81.

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EISSN 2564-7040