ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Evaluation of P-Wave Dispersion, Ventricular Functions, and Atrial Electromechanical Coupling in Children with Type 1 Diabetes Mellitus
1 Division of Pediatric Cardiology, Gaziantep University School of Medicine, Gaziantep, Turkey  
2 Department of Cardiology, Gaziantep University School of Medicine, Gaziantep, Turkey  
3 Division of Pediatric Endocrinology, Gaziantep University School of Medicine, Gaziantep, Turkey  
Eur J Ther 2018; 24: 250-254
DOI: 10.5152/EurJTher.2018.785
Key Words: Atrial electromechanical delay, children, diastolic function, left atrial mechanical function, type 1 diabetes mellitus

Objective: The present study aimed to evaluate ventricular diastolic function, inter- and intra-atrial conduction delay, and P wave dispersion in pediatric patients with type 1 diabetes mellitus (DM).


Methods: This study comprised 30 pediatric patients with type 1 DM and 30 healthy children served as the control group. P wave dispersion (Pd )was measured on a 12-channel ECG. Both systolic and diastolic functions of both ventricles were evaluated using conventional and tissue doppler imaging (TDI) echocardiography (ECHO). Atrial electromechanical delay was measured using TDI accompanied with electrocardiography (ECG).


Results: On conventional transthoracic echocardiography (ECHO), the mitral E/A ratio and isovolumetric relaxation times (IVRT) were different between the patients with type 1 DM and the control group (1.67±0.46 vs. 1.95±0.43, p=0.017 and 74.5±7.0 vs. 63.3±5.2, p<0.001, respectively). On TDI, LV septal peak systolic (Sm) and early diastolic (Em) velocities and Em/Am ratio were found to be significantly lower in the patients with type 1 DM than in the control group (p=0.047, p=0.003, and p=0.001, respectively). Regarding atrial electromechanical conduction, prolongation was detected in PA lateral, PA septal, PA tricuspid, and inter-atrial (PA lateral–PA tricuspid) and intra-atrial (PA septal–PA tricuspid) conduction delay (p<0.001, p<0.001, p<0.001, p<0.001, and p<0.05, respectively).


Conclusion: Our findings suggest that intra- and inter-atrial conduction delay, p wave dispersion, and ventricular diastolic functions are abnormal in patients with type 1 DM.

Key Words
AVES | Copyright © 2018 European Journal of Therapeutics | Latest Update: 11.03.2019