ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Comparison of Success Rates of Pleurodesis with Talc, and Holmium-YAG Laser in the Patients with Malignant Pleural Effusion
1 Department of Thoracic Surgery, Gaziantep University School of Medicine, Gaziantep, Turkey  
2 Clinic of Thoracic Surgery, Dr. Ersin Arslan State Hospital, Gaziantep, Turkey  
3 Thoracic Surgery Clinic, Ankara Güven Hospital, Ankara, Turkey  
4 Department of Biostatistics, Gaziantep University, Gaziantep, Turkey  
5 Department of Chest Diseases, Acibadem Taksim Hospital, İstanbul, Turkey  
6 Clinic of Thoracic Surgery, Medicalpark Hospital, Gaziantep, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2018.623
Key Words: Pleural Effusion, malignant, pleurodesis, holmium-yag lasers, talc
Abstract

Objective: We aimed to investigate the efficacy of Holmium-YAG (Ho-YAG) laser used via video-assisted thoracoscopic surgery and compare it with the talc slurry pleurodesis in patients with malignant pleural effusion (MPE).


Methods
: A total of 51 subjects with MPE were included. Patients were divided into two groups. In the laser group, pleurodesis was attempted with Holmium-YAG laser via uniportal video-thoracoscopy (VATS) in 30 subjects, and in the talc group, pleurodesis was attempted with talc slurry via a small bore chest tube in 21 subjects. The success rate of pleurodesis was evaluated by chest X-ray and/or thorax computed tomography obtained at the second month following pleurodesis and was graded as total success, partial success, or failure.


Results
: In the laser group, the success rates of pleurodesis were total success in 19 (63%) patients and partial in 7 (23%) patients. The volume of pleural effusion drained postoperatively was significantly different between success subgroups (total success subgroup vs. failure subgroup p=0.000, partial success subgroup vs. failure subgroup p=0.001). In the talc group, the success rates of pleurodesis were total success in 11 (52 %) patients and partial in 6 (29 %) patients. Comparison of success rates of pleurodesis between talc and laser groups showed no significant difference (p=0.725).


Conclusion
: We concluded that Holmium-YAG laser performed via video-thoracoscopy is a safe and effective option for pleurodesis in the management of MPE. However, there is no difference between Holmium-YAG laser and talk slurry pleurodesis in terms of procedure success rates.

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AVES | Copyright © 2018 European Journal of Therapeutics | Latest Update: 09.10.2018