ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
The frequency of celiac disease in Turkish children with cystic fibrosis
1 İstanbul University Cerrahpaşa Medical Faculty, Pediatric Gastroenterology, İstanbul, Turkey  
2 İstanbul University Cerrahpaşa Medical Faculty, Pathology, İstanbul, Turkey  
3 İstanbul University Cerrahpaşa Medical Faculty, Pediatric Pulmonology, İstanbul, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2018.701
Key Words: Celiac disease, cystic fibrosis, small intestine biopsy
Abstract

Objective: We aimed to investigate the frequency of CD in children with cystic fibrosis.


Patients and Methods
: This prospective study was carried out from October 2015 to March 2017. A total of 71 patients with CF and 73 age- and sex-matched healthy children were included. All groups were evaluated for CD in terms of clinical and laboratory findings. Firstly, total IgA and tissue transglutaminase IgA (tTG IgA) levels were measured. Anti-endomysium IgA antibodies (EMA) were analysed for those patients with positive tTG IgA. Gastroduodenoscopy was performed to patients with both positive tTG and EMA IgA antibodies. Results: Only eight patients (11.2%) had tTG IgA positivity, while four of them (5.6%) had positive EMA antibodies. The pathological results were consistent with Marsh 2 classification score in two patients. In addition to that, HLA-DQ2 is present in those two patients. Those patients were accepted as potential CD. Two patients who were thought to have potential CD were reassessed after one year and celiac screening tests were detected as positive again.


Conclusions
: Only two of 71 CF patients (2.8%) was diagnosed with potential CD. Our study results showed that there might be an association between CD and CF.


Cite this article as
: Şahin Y, Erkan T, Kutlu T, Kepil N, Ayzıt Kılınç A, Çullu Çokuğraş F, et al. The frequency of celiac disease in Turkish children with cystic fibrosis. Eur J Ther 2018; DOI: 10.5152/EurJTher.2018.701.

Key Words
Authors
All
Survey
AVES | Copyright © 2018 European Journal of Therapeutics | Latest Update: 09.10.2018