ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Evaluation of P-Wave Dispersion, Ventricular Functions and Atrial Electromechanical Coupling in children with Type 1 Diabetes Mellitus
1 Division of Pediatric Cardiology, Gaziantep University School of Medicine, Gaziantep, Turkey  
2 Department of Cardiology, Gaziantep University School of Medicine, Gaziantep, Turkey  
3 Division of Pediatric Endocrinology, Gaziantep University School of Medicine, Gaziantep, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2018.785
Key Words: atrial electromechanical delay, children, diastolic function, left atrial mechanical function, type 1 diabetes mellitus

Objective: The present study aimed to evaluate ventricular diastolic function, inter- and intra-atrial conduction delay, and P wave dispersion in pediatric patients with type 1 diabetes mellitus (DM).

: The study comprised 30 pediatric patients with type 1 DM and 30 healthy children served as the control group. Pd was measured on a 12-channel ECG. Both systolic and diastolic functions of both ventricles were evaluated using conventional and tissue Doppler imaging (TDI) echocardiography (ECHO). Atrial electromechanical delay was measured by tissue doppler imaging (TDI) accompanied with electrocardiography (ECG).

: On conventional transthoracic echocardiography (ECHO), the mitral E/A ratio and isovolumetric relaxation times (IVRT) were different between the type 1 DM patients and the control group (1.67 ± 0.46 vs. 1.95 ±0.43, P=0.017 and 74.5 ± 7.0 vs. 63.3 ± 5.2, P<0.001, respectively). On Tissue Doppler Imaging (TDI), LV septal peak systolic (Sm) and early diastolic (Em) velocities, and Em/Am ratio were found to be significantly lower in the type 1 DM patients than in the control group (P =0.047, P =0.003 and P =0.001, respectively). With regard to atrial electromechanical conduction, prolongation was detected in PA lateral, PA septal, PA tricuspid, and inter-atrial (PA lateral - PA tricuspid) and intra-atrial (PA septal - PA tricuspid) conduction delay (P<0.001, P<0.001, P<0.001, P<0.001, and P<0.05, respectively).

: Our findings suggest that intra- and inter-atrial conduction delay, P wave dispersion, and ventricular diastolic functions are abnormal in type 1 DM patients. 

Key Words
AVES | Copyright © 2018 European Journal of Therapeutics | Latest Update: 09.10.2018