ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Effects of gabapentin on carrageenan-induced inflammation, acute phase reactants and gastric mucus secretion in rats
1 Deparment of Pharmacology, Eskişehir Osmangazi University, School of Medicine, Eskişehir, Turkey  
2 Eskişehir Osmangazi University, Mahmudiye Riding Horse Vocational School, Eskişehir, Turkey  
3 Department of Biostatistics, Eskişehir Osmangazi University, School of Medicine, Eskişehir, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2018.543
Key Words: Gabapentin, antiinflammatory effect, gastric mucus, carrageenan-induced inflammation, cytokine levels
Abstract

Objective: Gabapentin which was firstly developed as an anticonvulsant agent has gained a great attention recently considering its pain relieving and antiinflammatory effects. This study was designed to investigate the antiinflammatory effect of gabapentin on carrageenan-induced paw edema and its gastric side effects by determining gastric mucus secretion in rats.


Methods
: Paw edema was induced with 1% carrageenan (CAR) immediately before intraperitoneal saline, gabapentin (GBP) (10, 30 mg/kg), diclofenac (DIC) (5 mg/kg) injections. Paw thickness was measured hourly during 6 hours. Serum cytokine levels were determined using ELISA. For the evaluation of gastric mucus secretion, saline, gabapentin, DIC were administered orally for 10 days. On the 10th day, stomachs were removed and gastric mucus of the glandular part was evaluated spectrophotometrically.


Results
: Both doses of GBP reduced paw thickness at 6th hour (p<0.05). GBP decreased levels of IL-1β, TNF-α levels similarly to diclofenac whereas it increased IL-10 levels less than diclofenac (p<0.05). Both doses of GBP and DIC decreased gastric mucus secretion compared to control (p<0.05).


Conclusion
: Our results suggest that GBP produces antiinflammatory effect comparable to DIC. However, effects of GBP on gastric mucus secretion were not better than DIC.

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