ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Relationship Between Thyroid Volume and Baseline Vitamin D Levels in New-onset Graves Disease
1 Department of Endocrinology and Metabolism Disorders, Başkent University School of Medicine, İstanbul, Turkey  
2 Department of Endocrinology and Metabolism Disorders, Kanuni Sultan Süleyman TrainiResearch Hospital, İstanbul, Turkey  
3 Department of Internal Medicine, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey  
4 Department of Nephrology, Kartal Training and Research Hospital, İstanbul, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2018.607
Key Words: Autoimmun disorders, 25 (OH) vitamin D, TRAb
Abstract

Objective: Serum vitamin D is shown to be decreased and associated with higher thyroid volumes in Graves disease. We aimed to investigate the relationship between thyroid volume and baseline serum vitamin D status in newly diagnosed Graves disease.
Methods: This is a monocenter cross sectional study with a total of 61 new-onset Graves disease patients (n:61, F:40, M:21) who were divided into two groups according to baseline serum vitamin D levels, as Group-1 (D vit<20; n:42) and Group-2 (D vit ≥20; n:19). Thyroid volume (mL) and isthmus measurements (mm) were compared between the two groups.
 

 

Results: There was an inverse correlation between baseline serum vitamin D levels and thyroid volume, TRAb, fT3 and PTH levels (p=0.02, r= -0.31; p=0.005, r=-0.36; p=0.04, r=-0.26; p=0.02, r=-0.32; respectively). Thyroid volume was also correlated with serum fT4, fT3, TRAb and TPOAb (p=0.001, r=0.426; p=0.001, r=0.50; p=0.04, r=0.26; p=0.001, r=0.42; respectively). Low vitamin D and high TgAb levels were significantly associated with thyroid volume in regression analysis (p=0.03, OR:18.7 [CI 95% 1.34-260.91] and p=0.04, OR: 16.6 [CI 95%1.07-255.64], respectively).
 

 

Conclusion: Baseline serum vitamin D levels are inversely related with thyroid volumes, fT3 and TRAb levels in new-onset Graves disease. In addition to several advantages, optimization of vitamin D levels would also be beneficial in the surveillance of these patients. However larger scale studies are required in order to make further suggestions

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AVES | Copyright © 2018 European Journal of Therapeutics | Latest Update: 02.08.2018