ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Relationship between Serum Magnesium Level and Insulin Resistance in Obese Non-diabetic and Diabetic Patients
1 Department of Biochemistry Science and Technology, Gaziantep University School of Medicine, Gaziantep, Turkey  
2 Department of Endocrinology And Metabolism, Gaziantep University School of Medicine, Gaziantep, Turkey  
Eur J Ther 2018; 24: 44-48
DOI: 10.5152/EurJTher.2017.136
Key Words: Type 2 diabetes mellitus, obesity, insulin resistance, magnesium
Abstract

 

 

 

Objective: Type 2 diabetes mellitus (T2DM) and obesity are multifactorial diseases that include interactions between hereditary and environmental factors. Our study aimed to evaluate the relationship between serum magnesium (Mg) level and insulin resistance (HOMA-IR) in obese non-diabetic subjects and obese patients with T2DM who were compared with healthy controls.

 

Methods: The present study included 120 subjects of both genders (age, 20-70 years). The subjects were divided into four groups: Group I included 30 healthy subjects as control (8 males and 22 females); group II included 30 obese non-diabetic subjects (6 males and 24 females) with the body mass index (BMI) ≥25 kg/m2; group III included 30 (14 males and 16 females) obese patients with T2DM and disease history <1 year; and group IV included 30 (17 males and 13 females) obese patients with T2DM and disease history >5 years. Endocrinology and metabolism specialists diagnosed T2DM patients. Serum Mg, fasting glucose, fasting insulin, and fasting lipids were measured including the patients’ weight and height. In addition, BMI and HOMA-IR were calculated.

 

Results: Serum Mg level significantly decreased in group IV (1.72±0.1 mg/dL) compared with group I (2.07±0.1 mg/dL; p<0.05). HOMA-IR significantly increased in group IV (7.9±7.0) compared with group I (1.03±0.3; p<0.05). In addition, serum fasting glucose, serum insulin, and fasting lipids were significantly higher in case groups than in the control group. The serum Mg level was inversely associated with age in all case groups. In group IV, a negative significant correlation was found between serum Mg level and age and HOMA-IR (p<0.01).

 

 

Conclusion: A low serum Mg level was found in obese patients with T2DM and obese non-diabetic subjects, whereas a high HOMA-IR level was found in obese patients with T2DM and obese non-diabetic subjects. Obese patients with T2DM show a negative correlation between the serum Mg level with HOMA-IR and age. We recommend measuring the serum Mg level regularly in obese patients with T2DM, especially in elderly patients, and patients who require supplementation.

 

How to cite: Hamid R, Sayıner ZA, Çelekli A, Araz M. Relationship between serum magnesium level and insulin resistance in obese non-diabetic and diabetic patients. Eur J Ther 2018; 24: 44-8.

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