ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
The Effect of Sedative Agents on Stress Hormones and High-Sensitive Troponin in Patients Catheterized by Permanent-tunnel Port Catheter
1 Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey  
2 Department of Biochemistry, Gaziantep University School of Medicine, Gaziantep, Turkey  
Eur J Ther 2018; 24: 22-29
DOI: 10.5152/EurJTher.2017.172
Key Words: Port catheter, sedation, anxiety, troponin


Objective: To evaluate the effects of sedation and analgesia combinations on pain scales, anxiety, adrenocorticotropic hormone (ACTH), cortisol, and high-sensitive troponin in patients with a central venous catheter.


Methods: The present study was prospectively conducted in 90 patients who had been indicated for port catheterization in hematology and oncology in the emergency medicine department of Gaziantep University Medical Faculty between March 1st and September 1st, 2015. The patients were divided into three groups of 30 each. Pain levels were assessed using the Visual Analog Scale, anxiety levels using the Beck Anxiety Scale, and blood samples were collected before (0 min) and after (30 min) the procedure in order to obtain ACTH, cortisol, and high-sensitive troponin values.


Results: No statistically significant differences were observed between the groups with regard to gender and age (p=0.836 and p=0.182, respectively). Anxiety significantly decreased in all three groups. A significant decrease in level of pain was found in patients administering midazolam-fentanyl and those who received propofol; a significant decrease in systolic and diastolic blood pressure was also observed in these two groups. In all three groups, no significant cortisol change was found; however, significant high-sensitive troponin values were observed. There was no significant difference between the groups.



Conclusion: Sedative agents can be used efficiently, safely, and easily in minor surgical procedures, such as central venous catheterization. We also recommend the use of analgesic drugs, in addition to anxiolytic and sedative agents, during invasive procedures conducted in the emergency room.



How to cite: Safi Y, Yıldırım C, Şen C, Sabak M, Nogay S, Taysi S. The effect of sedative agents on stress hormones and high-sensitive troponin in patients catheterized by permanent-tunnel port catheter, Eur J Ther 2018; 24: 22-9.

Key Words
AVES | Copyright © 2018 European Journal of Therapeutics | Latest Update: 13.12.2018