ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Factors Affecting Adverse Effects After Renal Transplantation
1 Department of Medical Pharmacology, Sanko University School of Medicine, Gaziantep, Turkey  
2 Department of Nursing, Institute of Health Sciences, Gaziantep, Turkey  
Eur J Ther ; : -
DOI: 10.5152/EurJTher.2017.281
Key Words: Kidney transplantation, ımmunosuppressive therapy, calcineurin inhibitors, side effects, dialysis
Abstract

 

Objective: The incidence of developed adverse effects in the recipients after renal transplantation were analyzed.

 

Methods:  A total of 206 patients (mean age was 41.40±11.88 years, 92.7% were between 46 to 59 years old, and 66.0% were male) who underwent renal transplantation between September 2016 and January 2017 were evaluated retrospectively. Information regarding the sociodemographic characteristics of the sample patients were collected with the "Sociodemographic Characteristics Data Collection Form", which was created by the researcher.

 

Results: Various advers effects were detected in 206 patients who participated in our study. The incidence of advers effects was significantly higher in the patients who had hypertension and chronic glomerulonephritis who underwent dialysis treatment during 0-12 months before renal transplantation, and who received a kidney transplant from a living donor (p=0.001). The incidence of advers effects related to the immunosuppressive drugs used aftertransplantation was significantly higher in the patients receiving mycophenolate mofetil+ steroid + tacrolimus and mycophenolate mofetil+steroid + cyclosporin, and weight gain was higher in the patients receiving the same group of drugs (p=0.001). There were no significant differences in terms of advers effects that occurred in other drug combinations

 

Conclusion: We found that many factors (immunosuppressive drugs, etc.) in patients with renal transplantation may be associated with the incidence of advers effects.

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