ISSN 2564-7784 | E-ISSN 2564-7040
1 Department of Pediatric Cardiology, Adana City Hospital, Adana, Turkey  
2 Department of Pediatric Cardiology, Afyon Kocatepe University Hospital, Afyonkarahisar, Turkey  
3 Department of Pharmacology, Afyon Kocatepe University Hospital, Afyonkarahisar, Turkey  
4 Department of Biochemistry, Afyon Kocatepe University Hospital, Afyonkarahisar, Turkey  
Eur J Ther ; : -


Objective: The present study aims to determine the demographic features, laboratory data of the Turkish children who are diagnosed with acute rheumatic carditis and to evaluate echocardiographic indices of both left ventricle (LV) and right ventricle (RV) systolic-diastolic functions at the time of diagnosis.


Methods: This is a retrospective review of 100 children who were hospitalized due to the diagnosis of Acute Rheumatic Fever (ARF) related acute stage carditis (group 1) and 100 healthy children (group 2) who were matched with respect to age and body mass index. All subjects underwent detailed 2D, Pulsed Doppler, tissue Doppler for assessment of both ventricular functions initially.


Results: Left ventricular internal diameter measured during end-systole was significantly increased and mitral annular plane excursion (MAPSE) is decreased in patients in comparison to the controls (p=0.005). Although E’ velocity derived from septal mitral annulus were significantly lower, isovolumetric contraction time (IVCT) and myocardial performance index (MPI) was increased in group 1 compared with controls. E’, A’, S’ velocities, IVCT and myocardial performance index measured from tricuspid annulus were found to be similar in the group 1 compared to the controls, although isovolumetric relaxation time (IVRT) was significantly prolonged.


Conclusion: We detected a subclinical reduction in the systolic and diastolic function of both ventricles in children with the first attack of acute rheumatic fever. ‘Pulsed’ and tissue Doppler techniques in pediatric ARF patients have an important role in assessing cardiac functions. 

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AVES | Copyright © 2018 European Journal of Therapeutics | Latest Update: 13.12.2018