ISSN 2564-7784 | E-ISSN 2564-7040
Original Article
Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats
1 Department of Physical Therapy and Rehabilitation, Gaziantep University Vocational Higher School, Gaziantep, Turkey  
2 Department of Biophysics, Gaziantep University School of Medicine, Gaziantep, Turkey  
3 Department of Biochemistry, Gaziantep University School of Medicine, Gaziantep, Turkey  
Eur J Ther 2017; 23: 152-158
DOI: 10.5152/EurJTher.2017.139
Key Words: Antioxidants, diabetes, free radicals, oxidative stress, pulsed electromagnetic fields
Abstract

Objective: The present study investigated the protective effects of a pulsed electromagnetic field (PEMF) in a rat model of diabetes by analyzing oxidative/nitrosative stress parameters.

 

Methods: Rats were randomly divided into four groups of eight each: a control group, a sham PEMF group, a diabetes group, and a diabetes+PEMF group. Diabetes was induced in the sham PEMF, diabetes, and diabetes+PEMF groups by treatment with 50 mg/kg streptozotocin (STZ). Rats in the sham PEMF group were treated identically, without running the instrument. Following the development of diabetes, rats in the diabetes+PEMF group were treated with PEMF for 60 min/day for 4 weeks.

 

Results: Levels of oxidants, such as malondialdehyde (MDA), nitric oxide (NO), and myeloperoxidase (MPO), and antioxidants, such as superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT), were measured in blood and liver tissue samples. MPO, MDA, and NO levels were significantly higher, and SOD levels significantly lower, in the sham PEMF and diabetes groups than in the control group (p<0.05 each), whereas the levels of all these four (i.e.: MPO, MDA, NO, and SOD) in the diabetes+PEMF group were close to those in the control group. GSH levels were significantly lower in the sham PEMF, diabetes, and diabetes+PEMF groups than in the control group (p<0.05 each), whereas CAT levels were similar in all the four groups.

 

Conclusion: Results indicate that PEMF affects MDA, NO, MPO, SOD, and GSH levels and regulates diabetes-associated damage by reducing oxidative stress and increasing the levels of antioxidants. PEMF may be a non-invasive treatment option for diabetes and associated complications.

 

How to cite: Gözen H, Demirel C, Akan M, Tarakçıoğlu M. Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats. Eur J Ther 2017; 23: 152-8.

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