ISSN 2564-7784 | E-ISSN 2564-7040
1 Gaziantep University, Medical School, Emergency Department, Gaziantep, Turkey  
2 Gaziantep University, Medical School, Biochemistry Department, Gaziantep, Turkey  
Eur J Ther ; : -


Objectives: To evaluate the effect of sedation and analgesia combinations on pain scales, anxiety, adrenocortotropic hormone (ACTH), cortisol, and high-sensitive troponinin patients with a central venous catheter.

Patients and Methods: This study was prospectively conducted in 90 patients who had been indicated for port catheterization in Hematology and Oncology in the Emergency Medicine Department between 01 March and 01 September 2015. Patients were divided into three groups of 30. Pain levels were assessed using the Visual Analog Scale, anxiety levels were evaluated using the Beck Anxiety Scale, and blood samples were taken before (0 min) and after the procedure (30 min) in order to obtain ACTH, cortisol and high-sensitive troponin values.

Results: There were no statistically significant differences between the groups with regard to gender and age (p=0.836 and p=0.182). Anxiety significantly decreased in all three groups. A significant decrease in level of pain was found in patients taking midazolam-fentanyl and those who received propofol, and a significant decrease in systolic and diastolic blood pressure was also observed in these two groups. In all three groups, no significant cortisol change was found, while significant high-sensitive troponin values were observed. There was no significant difference between the groups.


Conclusion: Sedative agents can be used efficiently, safely, and simply in minor surgical procedures, such as central venous catheterization. We also recommend the use of analgesics drugs, in addition to anxiolytic and sedative agents, during invasive procedures conducted in the emergency room.

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AVES | Copyright © 2018 European Journal of Therapeutics | Latest Update: 13.12.2018